smg smaug [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: smgprovided by FlyBase
Official Full Name: smaugprovided by FlyBase
Primary source: FLYBASE:FBgn0016070
Locus tag: Dmel_CG5263
See related: AllianceGenome:FB:FBgn0016070
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-D69; anonD69; CG5263; D69; Dmel\CG5263; Smaug; Smg; SmG; SMG
Summary: Enables myosin binding activity and translation repressor activity. Involved in establishment of RNA localization; negative regulation of translation; and positive regulation of mRNA catabolic process. Located in P-body. Is expressed in several structures, including antennal primordium; central brain primordium; ganglia; germline cell; and head epidermis primordium. Orthologous to human SAMD4A (sterile alpha motif domain containing 4A) and SAMD4B (sterile alpha motif domain containing 4B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 66F1-66F1; 3-28 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8990317..8997989, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8983417..8991089, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The F-box protein Bard (CG14317) targets the Smaug RNA-binding protein for destruction during the Drosophila maternal-to-zygotic transition.
Title: The F-box protein Bard (CG14317) targets the Smaug RNA-binding protein for destruction during the Drosophila maternal-to-zygotic transition.
Structural basis for binding of Drosophila Smaug to the GPCR Smoothened and to the germline inducer Oskar.
Title: Structural basis for binding of Drosophila Smaug to the GPCR Smoothened and to the germline inducer Oskar.
Smaug regulates the expression of mRNAs encoding glycolytic enzymes (hexokinase and phosophofructokinase), a proteasome regulatory subunit (Rpn7) as well as epigenetic (Su(z)12) and post-transcriptional (Bicaudal C) regulators.
Title: Global regulation of mRNA translation and stability in the early Drosophila embryo by the Smaug RNA-binding protein.
Smaug directly recruits Ago1 to nanos mRNA in a miRNA-independent manner, thereby repressing translation.
Title: microRNA-independent recruitment of Argonaute 1 to nanos mRNA through the Smaug RNA-binding protein.
This paper reports that the Smaug recognition elements in the 3' UTR of nanos (nos) mRNA govern the time- and ATP-dependent assembly of an exceedingly stable repressed ribonucleoprotein particle (RNP) in embryo extract.
Title: Smaug assembles an ATP-dependent stable complex repressing nanos mRNA translation at multiple levels.
Smaug accumulation thus coordinates progression through the maternal-to-zygotic transition
Title: An essential role for the RNA-binding protein Smaug during the Drosophila maternal-to-zygotic transition.
Data show that Smaug can recruit the CCR4-NOT deadenylase to trigger Hsp83 mRNA degradation despite the fact that it is being translated.
Title: Drosophila maternal Hsp83 mRNA destabilization is directed by multiple SMAUG recognition elements in the open reading frame.
RNA binds via the SAM domain of smaug.
Title: RNA recognition via the SAM domain of Smaug.
smaug has a domain that encodes a RNA-binding motif
Title: Crystallization and characterization of Smaug: a novel RNA-binding motif.
Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryo.
Title: Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryo.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	TAS Traceable Author Statement more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	TAS Traceable Author Statement more info	PubMed
enables mRNA regulatory element binding translation repressor activity	TAS Traceable Author Statement more info	PubMed
enables myosin binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation repressor activity	IDA Inferred from Direct Assay more info	PubMed
enables translation repressor activity	IEA Inferred from Electronic Annotation more info
enables translation repressor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in establishment of RNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	TAS Traceable Author Statement more info	PubMed
involved_in nuclear-transcribed mRNA poly(A) tail shortening	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA poly(A) tail shortening	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in piRNA-mediated gene silencing by mRNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA stability	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA stability	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: smaug

Names: CG5263-PA; CG5263-PB; CG5263-PC; CG5263-PD; CG5263-PE; SMAUG; dSmaug; smau; smg-PA; smg-PB; smg-PC; smg-PD; smg-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

8990317..8997989 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168309.3 → NP_729441.1 smaug, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729441.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1P7, B7Z0F4, B7Z0F5, Q23972, Q9V3T0, Q9VSS8

Related

FBpp0076276

Conserved Domains (3) summary

cd09557
Location:597 → 655

SAM_Smaug; SAM domain of Smaug subfamily

smart00454
Location:601 → 656

SAM; Sterile alpha motif

pfam09246
Location:656 → 763

PHAT; PHAT
NM_079263.3 → NP_523987.1 smaug, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523987.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1P7, B7Z0F4, B7Z0F5, Q23972, Q9V3T0, Q9VSS8

Related

FBpp0076277

Conserved Domains (3) summary

cd09557
Location:597 → 655

SAM_Smaug; SAM domain of Smaug subfamily

smart00454
Location:601 → 656

SAM; Sterile alpha motif

pfam09246
Location:656 → 763

PHAT; PHAT
NM_001144452.2 → NP_001137924.1 smaug, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137924.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23972

Conserved Domains (3) summary

cd09557
Location:597 → 655

SAM_Smaug; SAM domain of Smaug subfamily

smart00454
Location:601 → 656

SAM; Sterile alpha motif

pfam09246
Location:656 → 763

PHAT; PHAT
NM_168310.3 → NP_729442.1 smaug, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729442.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1P7, B7Z0F4, B7Z0F5, Q23972, Q9V3T0, Q9VSS8

Related

FBpp0076278

Conserved Domains (3) summary

cd09557
Location:597 → 655

SAM_Smaug; SAM domain of Smaug subfamily

smart00454
Location:601 → 656

SAM; Sterile alpha motif

pfam09246
Location:656 → 763

PHAT; PHAT
NM_001144453.2 → NP_001137925.1 smaug, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137925.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1P7, B7Z0F4, B7Z0F5, Q23972, Q9V3T0, Q9VSS8

Conserved Domains (3) summary

cd09557
Location:597 → 655

SAM_Smaug; SAM domain of Smaug subfamily

smart00454
Location:601 → 656

SAM; Sterile alpha motif

pfam09246
Location:656 → 763

PHAT; PHAT