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    Ciao1 Ciao1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36655, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ciao1provided by FlyBase
    Official Full Name
    Ciao1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033972
    Locus tag
    Dmel_CG12797
    See related
    AllianceGenome:FB:FBgn0033972
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12797; CiaO1; CIAO1; Dmel\CG12797
    Summary
    Predicted to be involved in iron-sulfur cluster assembly. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval muscle system; and larval visceral muscle cell. Orthologous to human CIAO1 (cytosolic iron-sulfur assembly component 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ciao1 in Genome Data Viewer
    Location:
    51C5-51C5; 2-72 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14853863..14855048, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10741368..10742553, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Structural maintenance of chromosomes 2 Neighboring gene Ercc1 Neighboring gene Hermansky-Pudlak Syndrome 1 Neighboring gene uncharacterized protein Neighboring gene U3 small nuclear riboprotein factor 55K

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A proteomics approach to identify targets of the ubiquitin-like molecule Urm1 in Drosophila melanogaster. Khoshnood B, et al. PLoS One, 2017. PMID 28953965, Free PMC Article
    2. Structural insights into Fe-S protein biogenesis by the CIA targeting complex. Kassube SA, et al. Nat Struct Mol Biol, 2020 Aug. PMID 32632277
    3. Ciao1 interacts with Crumbs and Xpd to regulate organ growth in Drosophila. Jung J, et al. Cell Death Dis, 2020 May 13. PMID 32404863, Free PMC Article
    4. Drosophila ERCC1 is required for a subset of MEI-9-dependent meiotic crossovers. Radford SJ, et al. Genetics, 2005 Aug. PMID 15944364, Free PMC Article
    5. Genetic and Genomic Response to Selection for Food Consumption in Drosophila melanogaster. Garlapow ME, et al. Behav Genet, 2017 Mar. PMID 27704301, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ciao1 interacts with Crumbs and Xpd to regulate organ growth in Drosophila.
      Title: Ciao1 interacts with Crumbs and Xpd to regulate organ growth in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron-sulfur cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic [4Fe-4S] assembly targeting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic [4Fe-4S] assembly targeting complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ciao1
    Names
    CG12797-PA
    Ciao1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14853863..14855048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137152.4 → NP_610996.1  Ciao1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610996.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K1Y4
      Related
      FBpp0086590
      Conserved Domains (3) summary
      COG2319
      Location:9 → 333
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:6 → 332
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:17 → 57
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K1Y4.1 Q7K1Y4

    Gene LinkOut

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