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    Nepl3 Neprilysin-like 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326172, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nepl3provided by FlyBase
    Official Full Name
    Neprilysin-like 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0031678
    Locus tag
    Dmel_CG31918
    See related
    AllianceGenome:FB:FBgn0031678
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.477; CG18592; CG31918; Dmel\CG31918
    Summary
    Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in nurse cell; organism; and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nepl3 in Genome Data Viewer
    Location:
    25C3-25C3; 2-15 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5055982..5058248, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5055982..5058248, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit h Neighboring gene senju Neighboring gene uncharacterized protein Neighboring gene Histone H3.3A Neighboring gene Regulatory particle non-ATPase 11 Neighboring gene long non-coding RNA:CR45291

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
    2. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    3. Microarray analysis of replicate populations selected against a wing-shape correlation in Drosophila melanogaster. Weber KE, et al. Genetics, 2008 Feb. PMID 18245369, Free PMC Article
    4. Parallel and population-specific gene regulatory evolution in cold-adapted fly populations. Huang Y, et al. Genetics, 2021 Jul 14. PMID 33989401, Free PMC Article
    5. Following the 'tracks': Tramtrack69 regulates epithelial tube expansion in the Drosophila ovary through Paxillin, Dynamin, and the homeobox protein Mirror. Peters NC, et al. Dev Biol, 2013 Jun 15. PMID 23545328, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Neprilysin-like 3
    Names
    CG31918-PA
    Nepl3-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5055982..5058248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135060.4 → NP_608904.1  Neprilysin-like 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608904.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMU6
      Related
      FBpp0078665
      Conserved Domains (1) summary
      cl14813
      Location:42 → 581
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMU6 Q9VMU6

    Gene LinkOut

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