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    l(3)72Dn lethal (3) 72Dn [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39774, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(3)72Dnprovided by FlyBase
    Official Full Name
    lethal (3) 72Dnprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263605
    Locus tag
    Dmel_CG5018
    See related
    AllianceGenome:FB:FBgn0263605
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5018; Dmel\CG5018; l(3)j5A4; UTP4
    Summary
    Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of small-subunit processome and t-UTP complex. Is expressed in organism. Human ortholog(s) of this gene implicated in cholestasis and primary biliary cholangitis. Orthologous to human UTP4 (UTP4 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(3)72Dn in Genome Data Viewer
    Location:
    72D10-72D10; 3-44 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16226126..16228737, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16219226..16221837, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43891 Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Methionine-CAT 1-3 Neighboring gene Thioredoxin-related transmembrane protein 3 Neighboring gene Programmed Cell Death 5 Neighboring gene Mediator complex subunit 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Scrutinizing the human TEX genes in the context of human male infertility. Sieper MH, et al. Andrology, 2024 Mar. PMID 37594251
    2. Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation. Sanchez CG, et al. Cell Stem Cell, 2016 Feb 4. PMID 26669894, Free PMC Article
    3. Transcriptional response to dietary restriction in Drosophila melanogaster. Ding F, et al. J Insect Physiol, 2014 Oct. PMID 24819200, Free PMC Article
    4. Molecular genetic analyses of polytene chromosome region 72A-D in Drosophila melanogaster reveal a gene desert in 72D. Cooper MT, et al. PLoS One, 2011. PMID 21853143, Free PMC Article
    5. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of t-UTP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lethal (3) 72Dn
    Names
    CG5018-PA
    CG5018-PB
    l(3)72Dn-PA
    l(3)72Dn-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16226126..16228737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140589.3 → NP_648846.2  lethal (3) 72Dn, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648846.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T021, Q9VUZ6
      Related
      FBpp0075239
      Conserved Domains (3) summary
      COG2319
      Location:99 → 573
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:74 → 106
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:20 → 268
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001275001.1 → NP_001261930.1  lethal (3) 72Dn, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261930.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFG1, Q8T021
      Conserved Domains (3) summary
      COG2319
      Location:57 → 529
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:74 → 106
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:20 → 268
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFG1 M9PFG1
    Q8T021 Q8T021
    Q9VUZ6 Q9VUZ6

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