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    EndoU Endoribonuclease U-specific [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41931, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EndoUprovided by FlyBase
    Official Full Name
    Endoribonuclease U-specificprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038381
    Locus tag
    Dmel_CG3303
    See related
    AllianceGenome:FB:FBgn0038381
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3303; dendoU; Dmel\CG3303
    Summary
    Enables RNA endonuclease activity. Involved in adult locomotory behavior; negative regulation of lipid catabolic process; and post-transcriptional regulation of gene expression. Is expressed in adult head; embryonic/larval posterior spiracle; and organism. Orthologous to human ENDOU (endonuclease, poly(U) specific). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See EndoU in Genome Data Viewer
    Location:
    89A8-89A8; 3-58 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15908398..15910367)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11734120..11736089)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene globin 1 Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46470 Neighboring gene F-box and leucine-rich repeat protein 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration. Laneve P, et al. Sci Rep, 2017 Jan 31. PMID 28139767, Free PMC Article
    2. The endoribonuclease Arlr is required to maintain lipid homeostasis by downregulating lipolytic genes during aging. Sun X, et al. Nat Commun, 2023 Oct 6. PMID 37803019, Free PMC Article
    3. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Hollien J, et al. Science, 2006 Jul 7. PMID 16825573
    4. GlycoFly: a database of Drosophila N-linked glycoproteins identified using SPEG--MS techniques. Baycin-Hizal D, et al. J Proteome Res, 2011 Jun 3. PMID 21480662
    5. Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster. Okada H, et al. Nat Commun, 2016 Sep 1. PMID 27582081, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of lipid catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in post-transcriptional gene silencing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    endoribonuclease U-specific
    Names
    CG3303-PA
    EndoU-PA
    drosophila endoribonuclease U-specific

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15908398..15910367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142251.4 → NP_650508.1  endoribonuclease U-specific [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650508.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960Q7, Q9VF14
      Related
      FBpp0082654
      Conserved Domains (1) summary
      pfam09412
      Location:55 → 319
      XendoU; Endoribonuclease XendoU
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VF14 Q9VF14

    Gene LinkOut

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