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    CG4408 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42762, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4408provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039073
    Locus tag
    Dmel_CG4408
    See related
    AllianceGenome:FB:FBgn0039073
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH09055; Dmel\CG4408
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in adult head and organism. Orthologous to human CPA5 (carboxypeptidase A5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4408 in Genome Data Viewer
    Location:
    94E13-94E13; 3-78 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23361889..23363574, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19187611..19189296, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Secretory 13 Neighboring gene Ribosomal protein S3 Neighboring gene long non-coding RNA:CR44322 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNApol-ϵ gene is indispensable for the survival and growth of Drosophila melanogaster. Verma A, et al. Genesis, 2012 Feb. PMID 21898761
    2. The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis. Lim DH, et al. FEBS Lett, 2011 Oct 3. PMID 21889502
    3. Age-dependent changes in the transcription profile of long-lived Drosophila over-expressing glutamate cysteine ligase. Radyuk SN, et al. Mech Ageing Dev, 2012 Jun. PMID 22579812
    4. Dissecting differential gene expression within the circadian neuronal circuit of Drosophila. Nagoshi E, et al. Nat Neurosci, 2010 Jan. PMID 19966839, Free PMC Article
    5. Burst of young retrogenes and independent retrogene formation in mammals. Pan D, et al. PLoS One, 2009. PMID 19325906, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4408-PA
    CG4408-PB
    Dmel_CG4408
    NP_001287482.1
    NP_651141.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23361889..23363574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142884.2 → NP_651141.2  uncharacterized protein Dmel_CG4408, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651141.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3M3A3, Q9VCM8
      Related
      FBpp0083823
      Conserved Domains (2) summary
      cd03860
      Location:179 → 472
      M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
      pfam02244
      Location:88 → 159
      Propep_M14; Carboxypeptidase activation peptide

    2. NM_001300553.1 → NP_001287482.1  uncharacterized protein Dmel_CG4408, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287482.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3M3A3, Q7JVX3
      Conserved Domains (2) summary
      cd03860
      Location:167 → 460
      M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
      pfam02244
      Location:76 → 147
      Propep_M14; Carboxypeptidase activation peptide
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JVX3 Q7JVX3
    Q9VCM8 Q9VCM8

    Gene LinkOut

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