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    PGAP3 Post-GPI attachment to proteins 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35570, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PGAP3provided by FlyBase
    Official Full Name
    Post-GPI attachment to proteins 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0033088
    Locus tag
    Dmel_CG3271
    See related
    AllianceGenome:FB:FBgn0033088
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3271; Dmel\CG3271
    Summary
    Predicted to enable hydrolase activity, acting on ester bonds. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 4. Orthologous to human PGAP3 (post-GPI attachment to proteins phospholipase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PGAP3 in Genome Data Viewer
    Location:
    42C4-42C4; 2-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6673604..6675061)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2561109..2562566)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Heparan sulfate C5-epimerase Neighboring gene uncharacterized protein Neighboring gene Ribonuclease P/MRP subunit p25 Neighboring gene Tyrosine decarboxylase 1 Neighboring gene long non-coding RNA:CR44164

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of Drosophila glucuronyl C5-epimerase: implications for developmental roles of heparan sulfate sulfation compensation and 2-O-sulfated glucuronic acid. Dejima K, et al. J Biol Chem, 2013 Nov 29. PMID 24133213, Free PMC Article
    2. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
    3. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
    4. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity, acting on ester bonds ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Post-GPI attachment to proteins 3
    Names
    CG3271-PA
    CG3271-PB
    PGAP3-PA
    PGAP3-PB
    Post-GPI attachment to proteins 3 ortholog
    NP_610223.1
    NP_724485.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6673604..6675061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165482.4 → NP_724485.1  Post-GPI attachment to proteins 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724485.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z6N0, Q7K0P4
      Related
      FBpp0085452
      Conserved Domains (1) summary
      pfam04080
      Location:65 → 306
      Per1; Per1-like

    2. NM_136379.4 → NP_610223.1  Post-GPI attachment to proteins 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610223.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K0P4
      Related
      FBpp0085453
      Conserved Domains (1) summary
      pfam04080
      Location:65 → 313
      Per1; Per1-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K0P4.2 Q7K0P4

    Gene LinkOut

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