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    HnRNP-K Heterogeneous nuclear ribonucleoprotein K [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43862, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HnRNP-Kprovided by FlyBase
    Official Full Name
    Heterogeneous nuclear ribonucleoprotein Kprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267791
    Locus tag
    Dmel_CG13425
    See related
    AllianceGenome:FB:FBgn0267791
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bancal; bl; Bl; BL; CG13425; dhnRNP K; Dmel\CG13425; hnRNP K; hnRNP-A1L; hrb57a; Hrb57A; l(2)k08305; Q18
    Summary
    Predicted to enable mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in chromatin and omega speckle. Is expressed in several structures, including adult brain cell body rind; adult head; cardiogenic mesoderm; epithelium; and germline cell. Human ortholog(s) of this gene implicated in Raynaud disease. Orthologous to human HNRNPK (heterogeneous nuclear ribonucleoprotein K). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See HnRNP-K in Genome Data Viewer
    Location:
    57A6-57A7; 2-91 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20587551..20606854)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16475056..16494359)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene mir-992 stem loop Neighboring gene Nnf1a Neighboring gene mir-7 stem loop Neighboring gene Hillarin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The dynamic nuclear redistribution of an hnRNP K-homologous protein during Drosophila embryo development and heat shock. Flexibility of transcription sites in vivo. Buchenau P, et al. J Cell Biol, 1997 Apr 21. PMID 9128243, Free PMC Article
    2. Cell nucleus: chromosome dynamics in nuclei of living cells. Zink D, et al. Curr Biol, 1998 Apr 23. PMID 9560332
    3. Visualizing chromatin dynamics in interphase nuclei. Gasser SM. Science, 2002 May 24. PMID 12029120
    4. Chriz, a chromodomain protein specific for the interbands of Drosophila melanogaster polytene chromosomes. Gortchakov AA, et al. Chromosoma, 2005 May. PMID 15821938
    5. The distribution of polycomb-group proteins during cell division and development in Drosophila embryos: impact on models for silencing. Buchenau P, et al. J Cell Biol, 1998 Apr 20. PMID 9548724, Free PMC Article

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that the hsromega transcripts regulate cellular levels of DIAP1 via the hnRNP Hrb57A, which physically interacts with DIAP1.
      Title: The developmentally active and stress-inducible noncoding hsromega gene is a novel regulator of apoptosis in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    involved_in regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in omega speckle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein K
    Names
    CG13425-PA
    CG13425-PB
    CG13425-PC
    CG13425-PD
    CG13425-PE
    CG13425-PF
    HnRNP-K-PA
    HnRNP-K-PB
    HnRNP-K-PC
    HnRNP-K-PD
    HnRNP-K-PE
    HnRNP-K-PF
    bancal
    bancal hnRNP
    heterogeneous nuclear ribonucleoprotein at 57A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20587551..20606854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206184.2 → NP_995906.1  heterogeneous nuclear ribonucleoprotein K, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995906.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBW0, Q7KA80
      Conserved Domains (1) summary
      cd02396
      Location:103 → 167
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

    2. NM_001169745.2 → NP_001163216.1  heterogeneous nuclear ribonucleoprotein K, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163216.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGN7, Q7KA80
      Conserved Domains (1) summary
      cd02396
      Location:97 → 161
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

    3. NM_206185.2 → NP_995907.1  heterogeneous nuclear ribonucleoprotein K, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995907.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBW1, Q7KA80
      Conserved Domains (1) summary
      cd02396
      Location:97 → 161
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

    4. NM_145883.3 → NP_665890.2  heterogeneous nuclear ribonucleoprotein K, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_665890.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBW3, D3DMD1
      Related
      FBpp0085537
      Conserved Domains (2) summary
      cd00105
      Location:339 → 402
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:14 → 78
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

    5. NM_001274173.1 → NP_001261102.1  heterogeneous nuclear ribonucleoprotein K, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261102.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBW1, Q7KA80
      Conserved Domains (1) summary
      cd02396
      Location:97 → 161
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

    6. NM_206183.3 → NP_995905.1  heterogeneous nuclear ribonucleoprotein K, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995905.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBW4, Q8IGP8
      Conserved Domains (1) summary
      cd00105
      Location:244 → 307
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZBW0 A1ZBW0
    A1ZBW1 A1ZBW1
    A1ZBW3 A1ZBW3
    A1ZBW4 A1ZBW4
    E1JGN7 E1JGN7
    Q7KA80 Q7KA80
    Q7KHL0 Q7KHL0
    Q8IGP8 Q8IGP8
    Q8SZZ6 Q8SZZ6
    Q9V948 Q9V948

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