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    Cbr4 carbonyl reductase 4 [ Mus musculus (house mouse) ]

    Gene ID: 234309, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cbr4provided by MGI
    Official Full Name
    carbonyl reductase 4provided by MGI
    Primary source
    MGI:MGI:2384567
    See related
    Ensembl:ENSMUSG00000031641 AllianceGenome:MGI:2384567
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A730083J17Rik
    Summary
    Predicted to enable several functions, including 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NADPH binding activity; and NADPH dehydrogenase (quinone) activity. Predicted to be involved in several processes, including daunorubicin metabolic process; doxorubicin metabolic process; and protein tetramerization. Located in mitochondrion. Orthologous to human CBR4 (carbonyl reductase 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 7.8), heart adult (RPKM 7.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cbr4 in Genome Data Viewer
    Location:
    8 B3.1; 8 31.18 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (61940768..61956534)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (61487734..61503500)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene SH3 domain containing ring finger 1 Neighboring gene RIKEN cDNA 5730405A17 gene Neighboring gene STARR-positive B cell enhancer ABC_E10501 Neighboring gene STARR-seq mESC enhancer starr_21586 Neighboring gene predicted gene, 53435 Neighboring gene STARR-seq mESC enhancer starr_21587 Neighboring gene STARR-seq mESC enhancer starr_21588 Neighboring gene STARR-seq mESC enhancer starr_21589 Neighboring gene palladin, cytoskeletal associated protein Neighboring gene STARR-seq mESC enhancer starr_21591 Neighboring gene STARR-seq mESC enhancer starr_21593 Neighboring gene predicted gene, 35254 Neighboring gene STARR-seq mESC enhancer starr_21597 Neighboring gene predicted gene, 51576

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression. Chiang DY, et al. Circulation, 2018 Oct 9. PMID 29669786, Free PMC Article
    2. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article
    3. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
    4. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
    5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC6971

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NAD(P)H dehydrogenase (quinone) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NADPH dehydrogenase (quinone) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH dehydrogenase (quinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables quinone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables quinone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables quinone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in daunorubicin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in daunorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in doxorubicin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in doxorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein heterotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    part_of oxidoreductase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of oxidoreductase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    3-oxoacyl-[acyl-carrier-protein] reductase
    Names
    3-ketoacyl-[acyl-carrier-protein] reductase beta subunit
    KAR beta subunit
    carbonyl reductase family member 4
    quinone reductase CBR4
    NP_663570.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145595.2 → NP_663570.2  3-oxoacyl-[acyl-carrier-protein] reductase

      See identical proteins and their annotated locations for NP_663570.2

      Status: VALIDATED

      Source sequence(s)
      AK043313, AK150763
      Consensus CDS
      CCDS40349.1
      UniProtKB/Swiss-Prot
      Q3UBY4, Q8BXV1, Q91VT4
      Related
      ENSMUSP00000034058.7, ENSMUST00000034058.14
      Conserved Domains (2) summary
      PRK05653
      Location:1 → 234
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated
      cl21454
      Location:3 → 232
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      61940768..61956534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VT4.2 GenPept UniProtKB/Swiss-Prot:Q91VT4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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