IKZF1 IKAROS family zinc finger 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IKZF1provided by HGNC
Official Full Name: IKAROS family zinc finger 1provided by HGNC
Primary source: HGNC:HGNC:13176
See related: Ensembl:ENSG00000185811 MIM:603023; AllianceGenome:HGNC:13176
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IK1; LYF1; LyF-1; CVID13; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452
Summary: This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
Expression: Biased expression in lymph node (RPKM 13.3), appendix (RPKM 8.6) and 10 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7p12.2

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (50303455..50405101)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (50464429..50566317)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (50343660..50472799)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity.
Title: Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity.
IgG4-related disease and B-cell malignancy due to an IKZF1 gain-of-function variant.
Title: IgG4-related disease and B-cell malignancy due to an IKZF1 gain-of-function variant.
IKZF1[PLUS] alterations contribute to outcome disparities in Hispanic/Latino children with B-lymphoblastic leukemia.
Title: IKZF1(PLUS) alterations contribute to outcome disparities in Hispanic/Latino children with B-lymphoblastic leukemia.
CCL2 mediated IKZF1 expression promotes M2 polarization of glioma-associated macrophages through CD84-SHP2 pathway.
Title: CCL2 mediated IKZF1 expression promotes M2 polarization of glioma-associated macrophages through CD84-SHP2 pathway.
IKZF1 and UBR4 gene variants drive autoimmunity and Th2 polarization in IgG4-related disease.
Title: IKZF1 and UBR4 gene variants drive autoimmunity and Th2 polarization in IgG4-related disease.
The GWAS SNP rs80207740 modulates erythrocyte traits via allele-specific binding of IKZF1 and targeting XPO7 gene.
Title: The GWAS SNP rs80207740 modulates erythrocyte traits via allele-specific binding of IKZF1 and targeting XPO7 gene.
Loss-of-phosphorylation of IKZF1 results in gain-of-function associated with immune dysregulation.
Title: Loss-of-phosphorylation of IKZF1 results in gain-of-function associated with immune dysregulation.
A novel IKZF1 variant in a family with autosomal dominant CVID: A case for expanding exon coverage in inborn errors of immunity.
Title: A novel IKZF1 variant in a family with autosomal dominant CVID: A case for expanding exon coverage in inborn errors of immunity.
IKZF1 rs4132601 and rs11978267 gene polymorphisms and paediatric systemic lupus erythematosus; relation to lupus nephritis.
Title: IKZF1 rs4132601 and rs11978267 gene polymorphisms and paediatric systemic lupus erythematosus; relation to lupus nephritis.
A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children.
Title: A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children.

Submit: New GeneRIF Correction See all GeneRIFs (301)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Pancytopenia due to IKZF1 mutations MedGen: C4225173 OMIM: 616873 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Confirmation of Childhood Acute Lymphoblastic Leukemia Variants, ARID5B and IKZF1, and Interaction with Parental Environmental Exposures. EBI GWAS Catalog EBI GWAS CatalogPubMed
Discovery and refinement of loci associated with lipid levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Germline genomic variants associated with childhood acute lymphoblastic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. EBI GWAS Catalog EBI GWAS CatalogPubMed
Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. EBI GWAS Catalog EBI GWAS CatalogPubMed
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Seventy-five genetic loci influencing the human red blood cell. EBI GWAS Catalog EBI GWAS CatalogPubMed
Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Ikaros is identified to interact with HIV-1 Tat in Jurkat cell by GST pull-down and by WB	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

RH64966 (e-PCR)
- UniSTS:44603

SGC33450 (e-PCR)
- UniSTS:74861

SHGC-36405 (e-PCR)
- UniSTS:61345

RH65205 (e-PCR)
- UniSTS:49089

GDB:1318324 (e-PCR)
- UniSTS:68556

HSC183_(GAP_102_G) (e-PCR)
- UniSTS:255208

HSC186_(GAP_20_X) (e-PCR)
- UniSTS:255211

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymphocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in pericentric heterochromatin	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: DNA-binding protein Ikaros

Names: CLL-associated antigen KW-6; ikaros family zinc finger protein 1; lymphoid transcription factor LyF-1; protein phosphatase 1, regulatory subunit 92; zinc finger protein, subfamily 1A, 1 (Ikaros)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_034231.1 RefSeqGene

Range

5634..106019

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GenBank, FASTA, Sequence Viewer (Graphics), LRG_1121

mRNA and Protein(s)

NM_001220765.3 → NP_001207694.1 DNA-binding protein Ikaros isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2, also known as Ikx) is shorter than isoform 1, and it contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:11489963). Both variants 2 and 14 encode isoform 2.

Source sequence(s)

AY377974, BC018349, BM148203, JX459579

Consensus CDS

CCDS59055.1

UniProtKB/Swiss-Prot

Q13422

UniProtKB/TrEMBL

R9R4D9

Related

ENSP00000352123.5, ENST00000359197.9

Conserved Domains (2) summary

sd00017
Location:119 → 139

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:132 → 156

zf-H2C2_2; Zinc-finger double domain
NM_001220767.2 → NP_001207696.1 DNA-binding protein Ikaros isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (4, also known as Ik-2(del) as described in PMID:9892693) is shorter than isoform 1. This isoform contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:9892693).

Source sequence(s)

JX459579, U40462

UniProtKB/TrEMBL

A0A8V8TMF3

Conserved Domains (2) summary

COG5048
Location:1 → 131

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:60 → 80

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001220768.2 → NP_001207697.1 DNA-binding protein Ikaros isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (5, also known as Ik-3 as described in PMID:12937159) is shorter than isoform 1. This isoform contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:9892693).

Source sequence(s)

JX459579, U40462

UniProtKB/Swiss-Prot

Q13422

UniProtKB/TrEMBL

R9R4D9

Conserved Domains (2) summary

sd00017
Location:119 → 139

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:132 → 156

zf-H2C2_2; Zinc-finger double domain
NM_001220770.2 → NP_001207699.1 DNA-binding protein Ikaros isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks an alternate in-frame exon in both the 5' and central coding regions, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (7, also known as Ik-4(del) as described in PMID:9892693), is shorter than isoform 1. This isoform contains only two N-terminal zinc finger motifs, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).

Source sequence(s)

JX459579, U40462

UniProtKB/TrEMBL

A0A8V8TMF3

Conserved Domains (4) summary

COG5048
Location:1 → 112

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:60 → 80

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:58 → 80

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:72 → 97

zf-H2C2_2; Zinc-finger double domain
NM_001220771.2 → NP_001207700.1 DNA-binding protein Ikaros isoform 8

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks three consecutive alternate in-frame exons in the central coding region, compared to variant 1. The encoded isoform (8, also known as Ik-5 as described in PMID:12937159) is shorter than isoform 1. This isoform contains only one N-terminal zinc finger motif, and represents a non-DNA-binding, dominant-negative isoform.

Source sequence(s)

BC018349, JX459579

Consensus CDS

CCDS69299.1

UniProtKB/TrEMBL

A0A8V8TMF3

Related

ENSP00000513806.1, ENST00000698575.1
NM_001291837.2 → NP_001278766.1 DNA-binding protein Ikaros isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (14) differs in the 5' UTR, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2, also known as Ikx) is shorter than isoform 1, and it contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:11489963). Both variants 2 and 14 encode isoform 2.

Source sequence(s)

BC018349, DB122945, JX459579

Consensus CDS

CCDS59055.1

UniProtKB/Swiss-Prot

Q13422

UniProtKB/TrEMBL

R9R4D9

Related

ENSP00000413025.1, ENST00000439701.2

Conserved Domains (2) summary

sd00017
Location:119 → 139

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:132 → 156

zf-H2C2_2; Zinc-finger double domain
NM_001291838.2 → NP_001278767.1 DNA-binding protein Ikaros isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (Ik-2) differs in the 5' UTR, and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (3, also known as Ik-2) is shorter than isoform 1, and is localized to the nucleus and contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:9892693).

Source sequence(s)

AK303586, DB122945, JX459579

Consensus CDS

CCDS78233.1

UniProtKB/Swiss-Prot

Q13422

UniProtKB/TrEMBL

R9R4D9

Related

ENSP00000396554.1, ENST00000438033.5

Conserved Domains (2) summary

COG5048
Location:1 → 131

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:60 → 80

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001291839.2 → NP_001278768.1 DNA-binding protein Ikaros isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (Ik-4) differs in the 5' UTR, and lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant 1. The encoded isoform (6, also known as Ik-4 as described in PMID:12937159), is shorter than isoform 1. This isoform contains only two N-terminal zinc finger motifs, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).

Source sequence(s)

AC233268, BC018349, DC391353, JX459579

UniProtKB/TrEMBL

A0A8V8TMF3

Conserved Domains (4) summary

COG5048
Location:1 → 112

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:60 → 80

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:58 → 80

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:72 → 97

zf-H2C2_2; Zinc-finger double domain
NM_001291840.1 → NP_001278769.1 DNA-binding protein Ikaros isoform Ik-6

Status: REVIEWED

Description

Transcript Variant: This variant (Ik-6) lacks four consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (Ik-6) is shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs, is localized to the cytoplasm and functions as a non-DNA-binding, dominant-negative isoform (PMIDs:12937159, 10463586).

Source sequence(s)

JX459579, U40462

UniProtKB/TrEMBL

A0A0A0MRA0
NM_001291841.1 → NP_001278770.1 DNA-binding protein Ikaros isoform Ik-7

Status: REVIEWED

Description

Transcript Variant: This variant (Ik-7) lacks two consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (Ik-7) is shorter than isoform 1. This isoform contains only one N-terminal zinc finger motif, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).

Source sequence(s)

JX459579, U40462

UniProtKB/TrEMBL

A0A087WU46

Related

ENSP00000478368.1, ENST00000615491.4

Conserved Domains (1) summary

sd00017
Location:60 → 81

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001291842.1 → NP_001278771.1 DNA-binding protein Ikaros isoform Ik-7(del)

Status: REVIEWED

Description

Transcript Variant: This variant (Ik-7(del)) lacks two consecutive in-frame exons in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (Ik-7(del)) is shorter than isoform 1. This isoform contains only one N-terminal zinc finger motif, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).

Source sequence(s)

JX459579, U40462

UniProtKB/TrEMBL

A0A087WU46

Conserved Domains (1) summary

sd00017
Location:60 → 81

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001291843.1 → NP_001278772.1 DNA-binding protein Ikaros isoform Ik-8

Status: REVIEWED

Description

Transcript Variant: This variant (Ik-8) lacks three consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (Ik-8) is shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).

Source sequence(s)

JX459579, U40462

UniProtKB/TrEMBL

A0A087WU46
NM_001291844.1 → NP_001278773.1 DNA-binding protein Ikaros isoform Ik-8(del)

Status: REVIEWED

Description

Transcript Variant: This variant (Ik-8(del)) lacks three consecutive in-frame exons in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (Ik-8(del)) is shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).

Source sequence(s)

JX459579, U40462

UniProtKB/TrEMBL

A0A087WU46
NM_001291845.2 → NP_001278774.1 DNA-binding protein Ikaros isoform 15

Status: REVIEWED

Description

Transcript Variant: This variant (15) lacks five 3' exons but contains an alternate 3' terminal exon, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (15) has a distinct C-terminus and is significantly shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs and is likely non-DNA-binding.

Source sequence(s)

AC124014, BC064594, DB148957

Consensus CDS

CCDS78232.1

UniProtKB/TrEMBL

C9JTB0

Related

ENSP00000388478.1, ENST00000413698.5
NM_001291846.2 → NP_001278775.1 DNA-binding protein Ikaros isoform 16

Status: REVIEWED

Description

Transcript Variant: This variant (16) lacks five 3' exons but contains two alternate 3' exons, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (16) has a distinct C-terminus and is significantly shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs and is likely non-DNA-binding. Both variants 16 and 17 encode isoform 16.

Source sequence(s)

AW337855, BM148203, BU537824

Consensus CDS

CCDS87502.1

UniProtKB/TrEMBL

A0A2R8Y4D3

Related

ENSP00000493696.1, ENST00000646110.1
NM_001291847.2 → NP_001278776.1 DNA-binding protein Ikaros isoform 16

Status: REVIEWED

Description

Transcript Variant: This variant (17) differs in the 5' UTR, and lacks five 3' exons but contains two alternate 3' exons, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (16) has a distinct C-terminus and is significantly shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs and is likely non-DNA-binding. Both variants 16 and 17 encode isoform 16.

Source sequence(s)

AW337855, BU537824, DB122945

Consensus CDS

CCDS87502.1

UniProtKB/TrEMBL

A0A2R8Y4D3

Related

ENSP00000494180.1, ENST00000492782.6
NM_001410879.1 → NP_001397808.1 DNA-binding protein Ikaros isoform 17

Status: REVIEWED

Source sequence(s)

AC124014, AC233268

Consensus CDS

CCDS94102.1

UniProtKB/TrEMBL

A0A8V8TNQ0
NM_006060.6 → NP_006051.1 DNA-binding protein Ikaros isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1 (also known as Ik-1 as described in PMID:12937159). This isoform contains four N-terminal zinc finger motifs, binds DNA, and is localized to the nucleus.

Source sequence(s)

BM148203, JX459579, U40462

Consensus CDS

CCDS75596.1

UniProtKB/Swiss-Prot

A4D260, B4E0Z1, D3DVM5, O00598, Q13422, Q53XL2, Q69BM4, Q8WVA3

Related

ENSP00000331614.3, ENST00000331340.8

Conserved Domains (2) summary

sd00017
Location:119 → 139

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:132 → 156

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

50303455..50405101

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011515058.3 → XP_011513360.1 DNA-binding protein Ikaros isoform X1

Conserved Domains (3) summary

COG5048
Location:187 → 343

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:163 → 183

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:176 → 200

zf-H2C2_2; Zinc-finger double domain
XM_011515059.4 → XP_011513361.1 DNA-binding protein Ikaros isoform X2

Conserved Domains (3) summary

COG5048
Location:187 → 529

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:163 → 183

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:176 → 200

zf-H2C2_2; Zinc-finger double domain
XM_011515067.4 → XP_011513369.1 DNA-binding protein Ikaros isoform X8

Conserved Domains (2) summary

sd00017
Location:163 → 183

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:176 → 200

zf-H2C2_2; Zinc-finger double domain
XM_047419727.1 → XP_047275683.1 DNA-binding protein Ikaros isoform X10
XM_011515071.3 → XP_011513373.1 DNA-binding protein Ikaros isoform X17

Conserved Domains (4) summary

COG5048
Location:101 → 175

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:104 → 124

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:102 → 124

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:116 → 141

zf-H2C2_2; Zinc-finger double domain
XM_047419739.1 → XP_047275695.1 DNA-binding protein Ikaros isoform X19
XM_011515061.4 → XP_011513363.1 DNA-binding protein Ikaros isoform X4

Conserved Domains (3) summary

COG5048
Location:167 → 323

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:143 → 163

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:156 → 180

zf-H2C2_2; Zinc-finger double domain
XM_047419723.1 → XP_047275679.1 DNA-binding protein Ikaros isoform X6
XM_011515070.3 → XP_011513372.1 DNA-binding protein Ikaros isoform X12

Conserved Domains (2) summary

sd00017
Location:143 → 163

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:156 → 180

zf-H2C2_2; Zinc-finger double domain
XM_047419731.1 → XP_047275687.1 DNA-binding protein Ikaros isoform X14
XM_011515072.3 → XP_011513374.1 DNA-binding protein Ikaros isoform X20

Conserved Domains (2) summary

COG5048
Location:25 → 155

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:84 → 104

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_011515074.3 → XP_011513376.1 DNA-binding protein Ikaros isoform X23

Conserved Domains (2) summary

COG5048
Location:25 → 155

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:84 → 104

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_011515077.3 → XP_011513379.1 DNA-binding protein Ikaros isoform X27

UniProtKB/TrEMBL

A0A8V8TMF3

Conserved Domains (4) summary

COG5048
Location:25 → 136

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:84 → 104

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:82 → 104

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:96 → 121

zf-H2C2_2; Zinc-finger double domain
XM_011515078.3 → XP_011513380.1 DNA-binding protein Ikaros isoform X29

UniProtKB/TrEMBL

A0A8V8TMF3

Conserved Domains (4) summary

COG5048
Location:25 → 136

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:84 → 104

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:82 → 104

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:96 → 121

zf-H2C2_2; Zinc-finger double domain
XM_047419726.1 → XP_047275682.1 DNA-binding protein Ikaros isoform X9

UniProtKB/Swiss-Prot

A4D260, B4E0Z1, D3DVM5, O00598, Q13422, Q53XL2, Q69BM4, Q8WVA3
XM_047419729.1 → XP_047275685.1 DNA-binding protein Ikaros isoform X11
XM_047419734.1 → XP_047275690.1 DNA-binding protein Ikaros isoform X16
XM_047419736.1 → XP_047275692.1 DNA-binding protein Ikaros isoform X18
XM_047419745.1 → XP_047275701.1 DNA-binding protein Ikaros isoform X25
XM_047419747.1 → XP_047275703.1 DNA-binding protein Ikaros isoform X26

UniProtKB/TrEMBL

A0A8V8TMF3
XM_011515063.3 → XP_011513365.1 DNA-binding protein Ikaros isoform X5

UniProtKB/TrEMBL

A0A8V8TNQ0

Related

ENSP00000513805.1, ENST00000698574.1

Conserved Domains (2) summary

sd00017
Location:139 → 159

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:152 → 176

zf-H2C2_2; Zinc-finger double domain
XM_047419744.1 → XP_047275700.1 DNA-binding protein Ikaros isoform X24
XM_047419735.1 → XP_047275691.1 DNA-binding protein Ikaros isoform X18
XM_011515065.3 → XP_011513367.1 DNA-binding protein Ikaros isoform X5

UniProtKB/TrEMBL

A0A8V8TNQ0

Conserved Domains (2) summary

sd00017
Location:139 → 159

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:152 → 176

zf-H2C2_2; Zinc-finger double domain
XM_047419724.1 → XP_047275680.1 DNA-binding protein Ikaros isoform X7
XM_047419730.1 → XP_047275686.1 DNA-binding protein Ikaros isoform X13

Conserved Domains (2) summary

sd00017
Location:139 → 159

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:152 → 176

zf-H2C2_2; Zinc-finger double domain
XM_047419732.1 → XP_047275688.1 DNA-binding protein Ikaros isoform X15
XM_047419740.1 → XP_047275696.1 DNA-binding protein Ikaros isoform X21

UniProtKB/TrEMBL

A0A2R8YFR0

Related

ENSP00000496655.2, ENST00000642219.2
XM_047419725.1 → XP_047275681.1 DNA-binding protein Ikaros isoform X9

UniProtKB/Swiss-Prot

A4D260, B4E0Z1, D3DVM5, O00598, Q13422, Q53XL2, Q69BM4, Q8WVA3
XM_047419728.1 → XP_047275684.1 DNA-binding protein Ikaros isoform X11
XM_047419733.1 → XP_047275689.1 DNA-binding protein Ikaros isoform X16
XM_047419738.1 → XP_047275694.1 DNA-binding protein Ikaros isoform X18
XM_017011668.2 → XP_016867157.1 DNA-binding protein Ikaros isoform X25

UniProtKB/Swiss-Prot

Q13422

Conserved Domains (2) summary

COG5048
Location:1 → 131

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:60 → 80

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_047419746.1 → XP_047275702.1 DNA-binding protein Ikaros isoform X26

UniProtKB/TrEMBL

A0A8V8TMF3
XM_047419750.1 → XP_047275706.1 DNA-binding protein Ikaros isoform X31

UniProtKB/TrEMBL

A0A8V8TMF3

Related

ENSP00000513804.1, ENST00000698573.1
XM_011515062.3 → XP_011513364.1 DNA-binding protein Ikaros isoform X5

UniProtKB/TrEMBL

A0A8V8TNQ0

Conserved Domains (2) summary

sd00017
Location:139 → 159

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:152 → 176

zf-H2C2_2; Zinc-finger double domain
XM_011515073.3 → XP_011513375.1 DNA-binding protein Ikaros isoform X21

UniProtKB/TrEMBL

A0A2R8YFR0

Conserved Domains (3) summary

sd00017
Location:80 → 100

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:78 → 100

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:92 → 117

zf-H2C2_2; Zinc-finger double domain
XM_047419748.1 → XP_047275704.1 DNA-binding protein Ikaros isoform X28

UniProtKB/TrEMBL

A0A8V8TMF3
XM_011515064.4 → XP_011513366.1 DNA-binding protein Ikaros isoform X5

UniProtKB/TrEMBL

A0A8V8TNQ0

Conserved Domains (2) summary

sd00017
Location:139 → 159

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:152 → 176

zf-H2C2_2; Zinc-finger double domain
XM_011515060.3 → XP_011513362.1 DNA-binding protein Ikaros isoform X3

Conserved Domains (2) summary

sd00017
Location:149 → 169

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:162 → 186

zf-H2C2_2; Zinc-finger double domain
XM_047419749.1 → XP_047275705.1 DNA-binding protein Ikaros isoform X30

UniProtKB/TrEMBL

A0A8V8TMF3

Conserved Domains (4) summary

COG5048
Location:2 → 122

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:70 → 90

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:68 → 90

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:82 → 107

zf-H2C2_2; Zinc-finger double domain
XM_047419741.1 → XP_047275697.1 DNA-binding protein Ikaros isoform X22
XM_047419742.1 → XP_047275698.1 DNA-binding protein Ikaros isoform X22
XM_047419743.1 → XP_047275699.1 DNA-binding protein Ikaros isoform X22

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

50464429..50566317

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054357028.1 → XP_054213003.1 DNA-binding protein Ikaros isoform X20
XM_054357009.1 → XP_054212984.1 DNA-binding protein Ikaros isoform X6
XM_054357041.1 → XP_054213016.1 DNA-binding protein Ikaros isoform X29

UniProtKB/TrEMBL

A0A8V8TMF3
XM_054357014.1 → XP_054212989.1 DNA-binding protein Ikaros isoform X10
XM_054357027.1 → XP_054213002.1 DNA-binding protein Ikaros isoform X19
XM_054357019.1 → XP_054212994.1 DNA-binding protein Ikaros isoform X14
XM_054357011.1 → XP_054212986.1 DNA-binding protein Ikaros isoform X13
XM_054357039.1 → XP_054213014.1 DNA-binding protein Ikaros isoform X32

UniProtKB/TrEMBL

A0A8V8TMF3
XM_054357002.1 → XP_054212977.1 DNA-binding protein Ikaros isoform X7
XM_054357033.1 → XP_054213008.1 DNA-binding protein Ikaros isoform X26

UniProtKB/TrEMBL

A0A8V8TMF3
XM_054357017.1 → XP_054212992.1 DNA-binding protein Ikaros isoform X16
XM_054357023.1 → XP_054212998.1 DNA-binding protein Ikaros isoform X21

UniProtKB/TrEMBL

A0A2R8YFR0
XM_054357001.1 → XP_054212976.1 DNA-binding protein Ikaros isoform X5

UniProtKB/TrEMBL

A0A8V8TNQ0
XM_054357004.1 → XP_054212979.1 DNA-binding protein Ikaros isoform X9

UniProtKB/Swiss-Prot

A4D260, B4E0Z1, D3DVM5, O00598, Q13422, Q53XL2, Q69BM4, Q8WVA3
XM_054357005.1 → XP_054212980.1 DNA-binding protein Ikaros isoform X5

UniProtKB/TrEMBL

A0A8V8TNQ0
XM_054357010.1 → XP_054212985.1 DNA-binding protein Ikaros isoform X7
XM_054357018.1 → XP_054212993.1 DNA-binding protein Ikaros isoform X13
XM_054357020.1 → XP_054212995.1 DNA-binding protein Ikaros isoform X15
XM_054357029.1 → XP_054213004.1 DNA-binding protein Ikaros isoform X21

UniProtKB/TrEMBL

A0A2R8YFR0
XM_054357012.1 → XP_054212987.1 DNA-binding protein Ikaros isoform X9

UniProtKB/Swiss-Prot

A4D260, B4E0Z1, D3DVM5, O00598, Q13422, Q53XL2, Q69BM4, Q8WVA3
XM_054357015.1 → XP_054212990.1 DNA-binding protein Ikaros isoform X11
XM_054357021.1 → XP_054212996.1 DNA-binding protein Ikaros isoform X16
XM_054357026.1 → XP_054213001.1 DNA-binding protein Ikaros isoform X18
XM_054357035.1 → XP_054213010.1 DNA-binding protein Ikaros isoform X25
XM_054357037.1 → XP_054213012.1 DNA-binding protein Ikaros isoform X26

UniProtKB/TrEMBL

A0A8V8TMF3
XM_054357043.1 → XP_054213018.1 DNA-binding protein Ikaros isoform X31

UniProtKB/TrEMBL

A0A8V8TMF3
XM_054357025.1 → XP_054213000.1 DNA-binding protein Ikaros isoform X18
XM_054357024.1 → XP_054212999.1 DNA-binding protein Ikaros isoform X18
XM_054357034.1 → XP_054213009.1 DNA-binding protein Ikaros isoform X24
XM_054357038.1 → XP_054213013.1 DNA-binding protein Ikaros isoform X26

UniProtKB/TrEMBL

A0A8V8TMF3
XM_054357016.1 → XP_054212991.1 DNA-binding protein Ikaros isoform X11
XM_054357022.1 → XP_054212997.1 DNA-binding protein Ikaros isoform X16
XM_054357008.1 → XP_054212983.1 DNA-binding protein Ikaros isoform X5

UniProtKB/TrEMBL

A0A8V8TNQ0
XM_054357036.1 → XP_054213011.1 DNA-binding protein Ikaros isoform X25
XM_054357013.1 → XP_054212988.1 DNA-binding protein Ikaros isoform X9

UniProtKB/Swiss-Prot

A4D260, B4E0Z1, D3DVM5, O00598, Q13422, Q53XL2, Q69BM4, Q8WVA3
XM_054357006.1 → XP_054212981.1 DNA-binding protein Ikaros isoform X5

UniProtKB/TrEMBL

A0A8V8TNQ0
XM_054357030.1 → XP_054213005.1 DNA-binding protein Ikaros isoform X21

UniProtKB/TrEMBL

A0A2R8YFR0
XM_054357040.1 → XP_054213015.1 DNA-binding protein Ikaros isoform X28

UniProtKB/TrEMBL

A0A8V8TMF3
XM_054357007.1 → XP_054212982.1 DNA-binding protein Ikaros isoform X5

UniProtKB/TrEMBL

A0A8V8TNQ0
XM_054357003.1 → XP_054212978.1 DNA-binding protein Ikaros isoform X3
XM_054357042.1 → XP_054213017.1 DNA-binding protein Ikaros isoform X30

UniProtKB/TrEMBL

A0A8V8TMF3
XM_054357031.1 → XP_054213006.1 DNA-binding protein Ikaros isoform X22
XM_054357032.1 → XP_054213007.1 DNA-binding protein Ikaros isoform X22

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001220766.1: Suppressed sequence

Description

NM_001220766.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
NM_001220769.1: Suppressed sequence

Description

NM_001220769.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
NM_001220772.1: Suppressed sequence

Description

NM_001220772.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_001220773.1: Suppressed sequence

Description

NM_001220773.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_001220774.1: Suppressed sequence

Description

NM_001220774.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_001220775.1: Suppressed sequence

Description

NM_001220775.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_001220776.1: Suppressed sequence

Description

NM_001220776.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.