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    ATO3 putative ammonium permease ATO3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851992, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ATO3
    Official Full Name
    putative ammonium permease ATO3
    Primary source
    SGD:S000002792
    Locus tag
    YDR384C
    See related
    AllianceGenome:SGD:S000002792; FungiDB:YDR384C; VEuPathDB:YDR384C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ammonium channel activity. Involved in ammonium transmembrane transport and nitrogen utilization. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ATO3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1241204..1242031, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein P2B Neighboring gene Nkp1p Neighboring gene elongation factor 2 Neighboring gene Mus81p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATO3 encoding a putative outward ammonium transporter is an RTG-independent retrograde responsive gene regulated by GCN4 and the Ssy1-Ptr3-Ssy5 amino acid sensor system. Guaragnella N, et al. J Biol Chem, 2003 Nov 14. PMID 12966084
    2. Evolutionary engineering reveals amino acid substitutions in Ato2 and Ato3 that allow improved growth of Saccharomyces cerevisiae on lactic acid. Baldi N, et al. FEMS Yeast Res, 2021 Jun 8. PMID 34042971
    3. Association of putative ammonium exporters Ato with detergent-resistant compartments of plasma membrane during yeast colony development: pH affects Ato1p localisation in patches. Ricicová M, et al. Biochim Biophys Acta, 2007 May. PMID 17395151
    4. Ato protein interactions in yeast plasma membrane revealed by fluorescence lifetime imaging (FLIM). Strachotová D, et al. Biochim Biophys Acta, 2012 Sep. PMID 22579979
    5. Ammonia pulses and metabolic oscillations guide yeast colony development. Palková Z, et al. Mol Biol Cell, 2002 Nov. PMID 12429834, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Evolutionary engineering reveals amino acid substitutions in Ato2 and Ato3 that allow improved growth of Saccharomyces cerevisiae on lactic acid.
      Title: Evolutionary engineering reveals amino acid substitutions in Ato2 and Ato3 that allow improved growth of Saccharomyces cerevisiae on lactic acid.
    2. there is an interaction between molecules of the same Ato protein, namely Ato1p-Ato1p and Ato3p-Ato3p, but not Ato2p-Ato2p
      Title: Ato protein interactions in yeast plasma membrane revealed by fluorescence lifetime imaging (FLIM).
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acetate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ammonium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ammonium transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ammonium transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitrogen utilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative ammonium permease ATO3
    NP_010672.1
    • Plasma membrane protein, putative ammonium transporter; regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1241204..1242031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180692.1 → NP_010672.1  TPA: putative ammonium permease ATO3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010672.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT18, Q12359
      UniProtKB/TrEMBL
      A6ZYY5, B3LFR6, C8Z5U8, G2WBC4, N1PAJ1
      Conserved Domains (1) summary
      COG1584
      Location:55 → 266
      SatP; Succinate-acetate transporter protein [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12359.1

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