Elovl7 ELOVL fatty acid elongase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Elovl7provided by MGI
Official Full Name: ELOVL fatty acid elongase 7provided by MGI
Primary source: MGI:MGI:1921809
See related: Ensembl:ENSMUSG00000021696 AllianceGenome:MGI:1921809
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9130013K24Rik
Summary: Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in 4th ventricle lateral recess; choroid plexus; lateral ventricle choroid plexus; and skin. Orthologous to human ELOVL7 (ELOVL fatty acid elongase 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in large intestine adult (RPKM 5.6), kidney adult (RPKM 5.5) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D2.1; 13 59.69 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (108350860..108423643)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (108214326..108287109)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals.
Title: Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals.
High Elovl7 expression is associated with progression of castration-resistant prostate cancer.
Title: Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1)

General gene information

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Markers

AI840082 (e-PCR)
- UniSTS:165891

D13Mit213 (e-PCR), detects polymorphism
- UniSTS:127029

BB397365 (e-PCR)
- UniSTS:208990

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fatty acid elongase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid elongase activity	IEA Inferred from Electronic Annotation more info
enables fatty acid elongase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fatty acid elongation, monounsaturated fatty acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid elongation, monounsaturated fatty acid	IEA Inferred from Electronic Annotation more info
involved_in fatty acid elongation, polyunsaturated fatty acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid elongation, polyunsaturated fatty acid	IEA Inferred from Electronic Annotation more info
involved_in fatty acid elongation, polyunsaturated fatty acid	ISO Inferred from Sequence Orthology more info
involved_in fatty acid elongation, saturated fatty acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid elongation, saturated fatty acid	ISO Inferred from Sequence Orthology more info
involved_in fatty acid elongation, saturated fatty acid	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-chain fatty-acyl-CoA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in unsaturated fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in very long-chain fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in very long-chain fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in very long-chain fatty acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: very long chain fatty acid elongase 7

Names: 3-keto acyl-CoA synthase Elovl7; ELOVL FA elongase 7; ELOVL family member 7, elongation of long chain fatty acids; elongation of very long chain fatty acids protein 7; elongation of very long chain fatty acids-like 7; very long chain 3-ketoacyl-CoA synthase 7; very long chain 3-oxoacyl-CoA synthase 7

NP_083277.3

EC 2.3.1.199

XP_006517841.1

EC 2.3.1.199

XP_036014092.1

EC 2.3.1.199

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029001.5 → NP_083277.3 very long chain fatty acid elongase 7

See identical proteins and their annotated locations for NP_083277.3

Status: VALIDATED

Source sequence(s)

AC161252, AK018616, AK049118, BQ175164

Consensus CDS

CCDS36779.1

UniProtKB/Swiss-Prot

Q8BX38, Q8BYY8, Q9D2Y9

Related

ENSMUSP00000022207.9, ENSMUST00000022207.10

Conserved Domains (1) summary

pfam01151
Location:30 → 269

ELO; GNS1/SUR4 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

108350860..108423643

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006517778.4 → XP_006517841.1 very long chain fatty acid elongase 7 isoform X2

Conserved Domains (1) summary

pfam01151
Location:1 → 182

ELO; GNS1/SUR4 family
XM_036158199.1 → XP_036014092.1 very long chain fatty acid elongase 7 isoform X1

Conserved Domains (1) summary

pfam01151
Location:1 → 239

ELO; GNS1/SUR4 family