Inpp4b inositol polyphosphate-4-phosphatase, type II [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Inpp4bprovided by MGI
Official Full Name: inositol polyphosphate-4-phosphatase, type IIprovided by MGI
Primary source: MGI:MGI:2158925
See related: Ensembl:ENSMUSG00000037940 AllianceGenome:MGI:2158925
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E130107I17Rik
Summary: Enables lipid binding activity; phosphatidylinositol bisphosphate phosphatase activity; and phosphatidylinositol trisphosphate phosphatase activity. Acts upstream of or within several processes, including negative regulation of osteoclast differentiation; regulation of bone remodeling; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; ear; genitourinary system; heart; and musculoskeletal system. Orthologous to human INPP4B (inositol polyphosphate-4-phosphatase type II B). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Broad expression in heart adult (RPKM 1.6), cerebellum adult (RPKM 1.4) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C2; 8 39.02 cM

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (82068895..82865553)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (81342266..82134312)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of B-1 cell numbers and B cell-mediated antibody production by Inpp4b.
Title: Regulation of B-1 cell numbers and B cell-mediated antibody production by Inpp4b.
Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity.
Title: Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity.
We showed that Inpp4b is an essential regulator of metabolic health. Male Inpp4b knockout mice fed high fat diet develop type 2 diabetes. Inpp4b expression protects the liver from steatosis, mediates insulin sensitivity, and links obesity to neoplastic changes in the prostate epithelium.
Title: INPP4B protects from metabolic syndrome and associated disorders.
The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.
Title: The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.
Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice.
Title: Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice.
data show that INPP4B modulates AR activity in normal prostate and its loss contributes to the AR-dependent transcriptional profile in prostate cancer.
Title: Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity.
Data provides evidence that INPP4B may play a role in regulating callosal axon formation by the formation of Satb2-positive pyramidal neurons and controlling axon polarization.
Title: Depletion of Inositol Polyphosphate 4-Phosphatase II Suppresses Callosal Axon Formation in the Developing Mice.
Results provide evidence that INPP4B is a bona fide tumor suppressor whose function is particularly important in situations of PTEN deficiency. Biochemical data demonstrates that INPP4B directly dephosphorylates PtdIns(3,4,5)P3.
Title: INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor.
Study provides evidence that INPP4B loss can promote follicular-like thyroid cancer progression and metastasis in the context of PTEN haploinsufficiency through the isoform-specific regulation of AKT signaling at the endosomes.
Title: In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.
ERalpha plays a protective role in bladder cancer initiation and growth at least partly via modulating the INPP4B/Akt pathway.
Title: Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway in vitro and in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

General gene information

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Markers

D8Mit262 (e-PCR), detects polymorphism
- UniSTS:131472

MHAa32b10.seq (e-PCR)
- UniSTS:125139

D8Mit104 (e-PCR), detects polymorphism
- UniSTS:131310

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables inositol-1,3,4-trisphosphate 4-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol-3,4-bisphosphate 4-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol bisphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol trisphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular calcium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of osteoclast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphatidylinositol dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of bone remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of nucleocytoplasmic transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: type II inositol 3,4-bisphosphate 4-phosphatase

Names: D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase; phosphatidylinositol-3,4-bisphosphate 4-phosphatase; phosphoinositide 4-phosphatase

NP_001019788.1

EC 3.1.3.66

NP_001284520.1

EC 3.1.3.66

NP_001284522.1

EC 3.1.3.66

NP_001284525.1

EC 3.1.3.66

XP_006530917.1

EC 3.1.3.66

XP_006530918.1

EC 3.1.3.66

XP_006530919.1

EC 3.1.3.66

XP_006530921.1

EC 3.1.3.66

XP_006530924.1

EC 3.1.3.66

XP_006530925.1

EC 3.1.3.66

XP_006530926.1

EC 3.1.3.66

XP_011246653.1

EC 3.1.3.66

XP_011246654.1

EC 3.1.3.66

XP_017168215.1

EC 3.1.3.66

XP_017168217.1

EC 3.1.3.66

XP_017168218.1

EC 3.1.3.66

XP_030099350.1

EC 3.1.3.66

XP_036009844.1

EC 3.1.3.66

XP_036009845.1

EC 3.1.3.66

XP_036009846.1

EC 3.1.3.66

XP_036009847.1

EC 3.1.3.66

XP_036009848.1

EC 3.1.3.66

XP_036009849.1

EC 3.1.3.66

XP_036009850.1

EC 3.1.3.66

XP_036009851.1

EC 3.1.3.66

XP_036009852.1

EC 3.1.3.66

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024617.3 → NP_001019788.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC115778, AK139397, BC064813, DQ296611

Consensus CDS

CCDS22446.1

UniProtKB/Swiss-Prot

Q6P1Y8

UniProtKB/TrEMBL

Q1A6U9

Related

ENSMUSP00000044466.7, ENSMUST00000042529.14

Conserved Domains (1) summary

cd04048
Location:39 → 158

C2A_Copine; C2 domain first repeat in Copine
NM_001297591.1 → NP_001284520.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK139397, AK141502, DQ296613

Consensus CDS

CCDS80901.1

UniProtKB/TrEMBL

E9PVM3, Q1A6U9

Related

ENSMUSP00000150541.2, ENSMUST00000217122.2

Conserved Domains (1) summary

cd04048
Location:39 → 175

C2A_Copine; C2 domain first repeat in Copine
NM_001297593.1 → NP_001284522.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate internal exon and uses an alternate last exon compared to variant 1. The resulting isoform (3) has shorter and distinct N- and C-termini compared to isoform 1.

Source sequence(s)

AC121136, AK141502, DQ296611, DQ296612

UniProtKB/TrEMBL

Q1A6V0

Conserved Domains (1) summary

cl14603
Location:25 → 114

C2; C2 domain
NM_001297596.1 → NP_001284525.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate last exon compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC121136, AK141502, DQ296611

Consensus CDS

CCDS80902.1

UniProtKB/TrEMBL

E9PVM1, Q1A6V1

Related

ENSMUSP00000148972.2, ENSMUST00000215332.2

Conserved Domains (1) summary

cd04048
Location:39 → 175

C2A_Copine; C2 domain first repeat in Copine

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

82068895..82865553

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153952.1 → XP_036009845.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X4

UniProtKB/TrEMBL

Q1A6V1

Conserved Domains (1) summary

cd04048
Location:39 → 175

C2A_Copine; C2 domain first repeat in Copine
XM_011248351.3 → XP_011246653.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

UniProtKB/TrEMBL

E9PVM3, Q1A6U9

Conserved Domains (1) summary

cd04048
Location:39 → 175

C2A_Copine; C2 domain first repeat in Copine
XM_036153951.1 → XP_036009844.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

UniProtKB/TrEMBL

E9PVM3, Q1A6U9

Conserved Domains (1) summary

cd04048
Location:39 → 175

C2A_Copine; C2 domain first repeat in Copine
XM_006530855.3 → XP_006530918.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

UniProtKB/TrEMBL

E9PVM3, Q1A6U9

Conserved Domains (1) summary

cd04048
Location:39 → 175

C2A_Copine; C2 domain first repeat in Copine
XM_030243490.1 → XP_030099350.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X2

UniProtKB/TrEMBL

Q1A6U9

Conserved Domains (1) summary

cd04048
Location:39 → 175

C2A_Copine; C2 domain first repeat in Copine
XM_006530856.3 → XP_006530919.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

UniProtKB/TrEMBL

E9PVM3, Q1A6U9

Conserved Domains (1) summary

cd04048
Location:39 → 175

C2A_Copine; C2 domain first repeat in Copine
XM_006530861.4 → XP_006530924.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X5

UniProtKB/TrEMBL

F8WJC1

Conserved Domains (1) summary

cl14603
Location:25 → 114

C2; C2 domain
XM_017312729.3 → XP_017168218.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X4

UniProtKB/TrEMBL

Q1A6V1

Conserved Domains (1) summary

cd04048
Location:39 → 175

C2A_Copine; C2 domain first repeat in Copine
XM_006530858.4 → XP_006530921.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X3

UniProtKB/TrEMBL

E9PVM1, Q1A6V1

Conserved Domains (1) summary

cd04048
Location:39 → 175

C2A_Copine; C2 domain first repeat in Copine
XM_036153959.1 → XP_036009852.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X10

UniProtKB/TrEMBL

Q1A6V1

Conserved Domains (1) summary

cd04048
Location:39 → 175

C2A_Copine; C2 domain first repeat in Copine
XM_006530854.4 → XP_006530917.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

UniProtKB/TrEMBL

E9PVM3, Q1A6U9

Conserved Domains (1) summary

cd04048
Location:39 → 175

C2A_Copine; C2 domain first repeat in Copine
XM_017312728.3 → XP_017168217.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X2

UniProtKB/TrEMBL

Q1A6U9

Conserved Domains (1) summary

cd04048
Location:39 → 175

C2A_Copine; C2 domain first repeat in Copine
XM_036153953.1 → XP_036009846.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X6

UniProtKB/TrEMBL

F8WJC1

Conserved Domains (1) summary

cl14603
Location:25 → 97

C2; C2 domain
XM_036153954.1 → XP_036009847.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X7

UniProtKB/TrEMBL

Q3URI3

Related

ENSMUSP00000150520.2, ENSMUST00000213285.2

Conserved Domains (1) summary

cd04048
Location:39 → 175

C2A_Copine; C2 domain first repeat in Copine
XM_011248352.3 → XP_011246654.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

UniProtKB/TrEMBL

E9PVM3, Q1A6U9

Conserved Domains (1) summary

cd04048
Location:39 → 175

C2A_Copine; C2 domain first repeat in Copine
XM_017312726.2 → XP_017168215.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

UniProtKB/TrEMBL

E9PVM3, Q1A6U9

Conserved Domains (1) summary

cd04048
Location:39 → 175

C2A_Copine; C2 domain first repeat in Copine
XM_036153955.1 → XP_036009848.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X8

UniProtKB/TrEMBL

F8WJC1
XM_036153958.1 → XP_036009851.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X8

UniProtKB/TrEMBL

F8WJC1

Related

ENSMUSP00000132156.2, ENSMUST00000170160.8
XM_006530862.4 → XP_006530925.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X8

UniProtKB/TrEMBL

F8WJC1
XM_036153956.1 → XP_036009849.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X9

UniProtKB/TrEMBL

Q1A6V0
XM_006530863.5 → XP_006530926.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X8

UniProtKB/TrEMBL

F8WJC1

Related

ENSMUSP00000105477.3, ENSMUST00000109851.3
XM_036153957.1 → XP_036009850.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform X9

UniProtKB/TrEMBL

Q1A6V0