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    Csnk1g1 casein kinase 1, gamma 1 [ Mus musculus (house mouse) ]

    Gene ID: 214897, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Csnk1g1provided by MGI
    Official Full Name
    casein kinase 1, gamma 1provided by MGI
    Primary source
    MGI:MGI:2660884
    See related
    Ensembl:ENSMUSG00000032384 AllianceGenome:MGI:2660884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9130020E21Rik
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in endocytosis; positive regulation of canonical Wnt signaling pathway; and signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in central nervous system; genitourinary system; retina; and skin. Orthologous to human CSNK1G1 (casein kinase 1 gamma 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 3.9), whole brain E14.5 (RPKM 3.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Csnk1g1 in Genome Data Viewer
    Location:
    9 C; 9 35.6 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65816235..65952297)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65908968..66045015)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene predicted gene, 53535 Neighboring gene STARR-positive B cell enhancer ABC_E6756 Neighboring gene STARR-seq mESC enhancer starr_24473 Neighboring gene PCNA clamp associated factor Neighboring gene predicted gene, 23248 Neighboring gene predicted gene, 22657 Neighboring gene STARR-positive B cell enhancer mm9_chr9:65852147-65852448 Neighboring gene STARR-positive B cell enhancer ABC_E6757 Neighboring gene STARR-positive B cell enhancer ABC_E11412 Neighboring gene peptidylprolyl isomerase B Neighboring gene sorting nexin 22 Neighboring gene STARR-seq mESC enhancer starr_24475 Neighboring gene STARR-positive B cell enhancer ABC_E5080 Neighboring gene sorting nexin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence of a cDNA encoding an alternative form of LEF-1. Fujimoto S, et al. Nucleic Acids Res, 1993 Sep 11. PMID 8415007, Free PMC Article
    2. Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3. Lee SY, et al. Cell Death Dis, 2019 Dec 4. PMID 31801942, Free PMC Article
    3. Physiological role for casein kinase 1 in glutamatergic synaptic transmission. Chergui K, et al. J Neurosci, 2005 Jul 13. PMID 16014721, Free PMC Article
    4. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Unda BK, et al. Mol Psychiatry, 2023 Apr. PMID 36604605, Free PMC Article
    5. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    casein kinase I isoform gamma-1; casein kinase I
    Names
    CKI-gamma 1
    casein kinase I, gamma 1
    NP_775277.2
    XP_006511071.1
    XP_011241005.1
    XP_011241006.1
    XP_011241007.1
    XP_011241008.1
    XP_011241009.1
    XP_011241010.1
    XP_011241011.1
    XP_011241012.1
    XP_011241014.1
    XP_030100085.1
    XP_030100087.1
    XP_036010717.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173185.3 → NP_775277.2  casein kinase I isoform gamma-1

      Status: VALIDATED

      Source sequence(s)
      AC112676, AC151906
      Consensus CDS
      CCDS23300.1
      UniProtKB/Swiss-Prot
      E9QPK6, Q8BTH8
      UniProtKB/TrEMBL
      A0A0U1RP94
      Related
      ENSMUSP00000034949.4, ENSMUST00000034949.10
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 418
      CK1gamma_C; Casein kinase 1 gamma C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      65816235..65952297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511008.4 → XP_006511071.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A0U1RP94
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 429
      CK1gamma_C; Casein kinase 1 gamma C terminal

    2. XM_030244227.2 → XP_030100087.1  casein kinase I isoform X2

      UniProtKB/Swiss-Prot
      E9QPK6, Q8BTH8
      UniProtKB/TrEMBL
      A0A0U1RP94
      Related
      ENSMUSP00000145947.2, ENSMUST00000206594.2
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 418
      CK1gamma_C; Casein kinase 1 gamma C terminal

    3. XM_011242704.2 → XP_011241006.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A0U1RP94
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 429
      CK1gamma_C; Casein kinase 1 gamma C terminal

    4. XM_011242703.2 → XP_011241005.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A0U1RP94
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 429
      CK1gamma_C; Casein kinase 1 gamma C terminal

    5. XM_011242709.3 → XP_011241011.1  casein kinase I isoform X3

      UniProtKB/TrEMBL
      A0A0U1RPM8, Q6P2B2
      Related
      ENSMUSP00000113160.2, ENSMUST00000117849.3
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 381
      CK1gamma_C; Casein kinase 1 gamma C terminal

    6. XM_011242710.2 → XP_011241012.1  casein kinase I isoform X4

      UniProtKB/TrEMBL
      A0A0U1RNW0, A0A0U1RPM8
      Related
      ENSMUSP00000145724.2, ENSMUST00000205379.2
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 381
      CK1gamma_C; Casein kinase 1 gamma C terminal

    7. XM_011242707.2 → XP_011241009.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A0U1RP94
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 429
      CK1gamma_C; Casein kinase 1 gamma C terminal

    8. XM_011242706.2 → XP_011241008.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A0U1RP94
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 429
      CK1gamma_C; Casein kinase 1 gamma C terminal

    9. XM_011242705.2 → XP_011241007.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A0U1RP94
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 429
      CK1gamma_C; Casein kinase 1 gamma C terminal

    10. XM_011242712.3 → XP_011241014.1  casein kinase I isoform X5

      UniProtKB/TrEMBL
      A0A0U1RPD7, A0A0U1RPM8
      Related
      ENSMUSP00000145938.2, ENSMUST00000130798.3
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 388
      CK1gamma_C; Casein kinase 1 gamma C terminal

    11. XM_011242708.3 → XP_011241010.1  casein kinase I isoform X2

      UniProtKB/Swiss-Prot
      E9QPK6, Q8BTH8
      UniProtKB/TrEMBL
      A0A0U1RP94
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 418
      CK1gamma_C; Casein kinase 1 gamma C terminal

    12. XM_030244225.2 → XP_030100085.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A0U1RP94
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 429
      CK1gamma_C; Casein kinase 1 gamma C terminal

    13. XM_036154824.1 → XP_036010717.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A0U1RP94
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 429
      CK1gamma_C; Casein kinase 1 gamma C terminal

    RNA

    1. XR_003947839.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BTH8.2 GenPept UniProtKB/Swiss-Prot:Q8BTH8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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