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    UBR2 ubiquitin protein ligase E3 component n-recognin 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 527153, updated on 30-Jan-2025

    Summary

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    Official Symbol
    UBR2provided by VGNC
    Official Full Name
    ubiquitin protein ligase E3 component n-recognin 2provided by VGNC
    Primary source
    VGNC:VGNC:36617
    See related
    BGD:BT27332; EnsemblRapid:ENSBTAG00070028194
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See UBR2 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    53
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (16255437..16367802)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene peripherin 2 Neighboring gene tubulin folding cofactor C

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase UBR2
    NP_001179567.1
    XP_005223503.1
    XP_005223504.1
    XP_005223505.1
    XP_010816502.1
    XP_024839388.1
    XP_059736339.1
    XP_059736340.1
    XP_059736341.1
    XP_059736342.1
    XP_059736343.1
    XP_059736344.1
    XP_059736345.1
    XP_059736346.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192638.1 → NP_001179567.1  E3 ubiquitin-protein ligase UBR2

      See identical proteins and their annotated locations for NP_001179567.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000023
      UniProtKB/TrEMBL
      A0AAA9RZR2, E1BCW1
      Related
      ENSBTAP00070038607.1, ENSBTAT00070064257.1
      Conserved Domains (2) summary
      pfam02207
      Location:99 → 166
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:222 → 300
      ClpS; ATP-dependent Clp protease adaptor protein ClpS

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      16255437..16367802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059880356.1 → XP_059736339.1  E3 ubiquitin-protein ligase UBR2 isoform X4

      UniProtKB/TrEMBL
      A0AAA9RZR2

    2. XM_005223446.5 → XP_005223503.1  E3 ubiquitin-protein ligase UBR2 isoform X1

      See identical proteins and their annotated locations for XP_005223503.1

      UniProtKB/TrEMBL
      A0AAA9RZR2, A0AAA9SBZ8
      Related
      ENSBTAP00070038673.1, ENSBTAT00070064358.1
      Conserved Domains (2) summary
      pfam02207
      Location:99 → 166
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:222 → 300
      ClpS; ATP-dependent Clp protease adaptor protein ClpS

    3. XM_010818200.4 → XP_010816502.1  E3 ubiquitin-protein ligase UBR2 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LVP0, A0AAA9RZR2
      Related
      ENSBTAP00070038686.1, ENSBTAT00070064375.1
      Conserved Domains (2) summary
      pfam02207
      Location:99 → 166
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:222 → 300
      ClpS; ATP-dependent Clp protease adaptor protein ClpS

    4. XM_005223447.5 → XP_005223504.1  E3 ubiquitin-protein ligase UBR2 isoform X2

      UniProtKB/TrEMBL
      A0AAA9RZR2
      Conserved Domains (2) summary
      pfam02207
      Location:99 → 166
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:222 → 300
      ClpS; ATP-dependent Clp protease adaptor protein ClpS

    5. XM_059880358.1 → XP_059736341.1  E3 ubiquitin-protein ligase UBR2 isoform X7

    6. XM_059880359.1 → XP_059736342.1  E3 ubiquitin-protein ligase UBR2 isoform X8

    7. XM_059880360.1 → XP_059736343.1  E3 ubiquitin-protein ligase UBR2 isoform X9

    8. XM_059880361.1 → XP_059736344.1  E3 ubiquitin-protein ligase UBR2 isoform X10

    9. XM_059880362.1 → XP_059736345.1  E3 ubiquitin-protein ligase UBR2 isoform X11

    10. XM_059880363.1 → XP_059736346.1  E3 ubiquitin-protein ligase UBR2 isoform X12

    11. XM_005223448.5 → XP_005223505.1  E3 ubiquitin-protein ligase UBR2 isoform X13

      See identical proteins and their annotated locations for XP_005223505.1

      Conserved Domains (2) summary
      pfam02207
      Location:99 → 166
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:222 → 301
      ClpS; ATP-dependent Clp protease adaptor protein ClpS

    12. XM_024983620.2 → XP_024839388.1  E3 ubiquitin-protein ligase UBR2 isoform X5

      UniProtKB/TrEMBL
      A0AAA9RZR2
      Related
      ENSBTAP00070038582.1, ENSBTAT00070064214.1
      Conserved Domains (2) summary
      pfam02617
      Location:83 → 162
      ClpS; ATP-dependent Clp protease adaptor protein ClpS
      cl17238
      Location:968 → 1083
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    13. XM_059880357.1 → XP_059736340.1  E3 ubiquitin-protein ligase UBR2 isoform X6

      UniProtKB/TrEMBL
      A0AAA9RZR2

    RNA

    1. XR_009492471.1 RNA Sequence

    2. XR_009492472.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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