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    LOXL4 lysyl oxidase like 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 281904, updated on 1-Jan-2025

    Summary

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    Official Symbol
    LOXL4provided by VGNC
    Official Full Name
    lysyl oxidase like 4provided by VGNC
    Primary source
    VGNC:VGNC:55958
    See related
    BGD:BT11813; Ensembl:ENSBTAG00000020895
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See LOXL4 in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (19336042..19358394, complement)

    Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene cartilage acidic protein 1 Neighboring gene R3H domain and coiled-coil containing 1 like Neighboring gene uncharacterized LOC112444518 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 2 Neighboring gene microRNA mir-1287

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. LOXL4 is induced by transforming growth factor β1 through Smad and JunB/Fra2 and contributes to vascular matrix remodeling. Busnadiego O, et al. Mol Cell Biol, 2013 Jun. PMID 23572561, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein-lysine 6-oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in collagen fibril organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-lysine oxidation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysyl oxidase homolog 4
    Names
    lysyl oxidase-like protein 4
    NP_776809.1
    XP_024841236.1
    XP_059737707.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174384.3 → NP_776809.1  lysyl oxidase homolog 4 precursor

      See identical proteins and their annotated locations for NP_776809.1

      Status: PROVISIONAL

      Source sequence(s)
      AF529202
      UniProtKB/Swiss-Prot
      Q8MJ24
      UniProtKB/TrEMBL
      G1K200
      Related
      ENSBTAP00000027838.6, ENSBTAT00000027838.6
      Conserved Domains (3) summary
      smart00202
      Location:33 → 134
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:39 → 134
      SRCR; Scavenger receptor cysteine-rich domain
      pfam01186
      Location:534 → 729
      Lysyl_oxidase; Lysyl oxidase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      19336042..19358394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024985468.2 → XP_024841236.1  lysyl oxidase homolog 4 isoform X1

      UniProtKB/TrEMBL
      G1K200
      Conserved Domains (2) summary
      smart00202
      Location:33 → 134
      SR; Scavenger receptor Cys-rich
      pfam01186
      Location:534 → 733
      Lysyl_oxidase; Lysyl oxidase

    2. XM_059881724.1 → XP_059737707.1  lysyl oxidase homolog 4 isoform X2

      UniProtKB/TrEMBL
      G1K200
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MJ24.1 GenPept UniProtKB/Swiss-Prot:Q8MJ24

    Gene LinkOut

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    Research Materials