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    AHCYL2 adenosylhomocysteinase like 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 532836, updated on 29-Jan-2025

    Summary

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    Official Symbol
    AHCYL2provided by VGNC
    Official Full Name
    adenosylhomocysteinase like 2provided by VGNC
    Primary source
    VGNC:VGNC:25752
    See related
    BGD:BT17515; Ensembl:ENSBTAG00000001754
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    IRBIT2
    Orthologs
    human mouse all
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    Genomic context

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    See AHCYL2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (93142655..93333823)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene tetraspanin 33 Neighboring gene smoothened, frizzled class receptor Neighboring gene heterogeneous nuclear ribonucleoproteins A2/B1-like Neighboring gene uncharacterized LOC132345129 Neighboring gene zinc finger protein 512-like Neighboring gene striatin interacting protein 2 Neighboring gene small lysine rich protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. AHCYL2 (long-IRBIT) as a potential regulator of the electrogenic Na(+)-HCO3(-) cotransporter NBCe1-B. Yamaguchi S, et al. FEBS Lett, 2014 Mar 3. PMID 24472682
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The cytosolic ionic conditions appropriate for AHCYL2 to function might be different from IRBIT.
      Title: AHCYL2 (long-IRBIT) as a potential regulator of the electrogenic Na(+)-HCO3(-) cotransporter NBCe1-B.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in S-adenosylmethionine cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenosylhomocysteinase 3
    Names
    IP(3)Rs binding protein released with IP(3) 2
    S-adenosylhomocysteine hydrolase-like 2
    adoHcyase 3
    long-IRBIT
    putative adenosylhomocysteinase 3
    NP_001094613.1
    XP_005205764.3
    XP_005205765.1
    XP_005205766.1
    XP_005205767.1
    XP_005205768.1
    XP_059741616.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101143.1 → NP_001094613.1  adenosylhomocysteinase 3

      See identical proteins and their annotated locations for NP_001094613.1

      Status: PROVISIONAL

      Source sequence(s)
      BC148036
      UniProtKB/Swiss-Prot
      A6QLP2
      UniProtKB/TrEMBL
      A0A3Q1LYW5
      Conserved Domains (2) summary
      PRK05476
      Location:185 → 605
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
      pfam05221
      Location:185 → 610
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      93142655..93333823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005205707.5 → XP_005205764.3  adenosylhomocysteinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LYW5

    2. XM_059885633.1 → XP_059741616.1  adenosylhomocysteinase 3 isoform X6

    3. XM_005205710.4 → XP_005205767.1  adenosylhomocysteinase 3 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1LYW5, A0A3Q1MBY7
      Related
      ENSBTAP00070033247.1, ENSBTAT00070055334.1
      Conserved Domains (2) summary
      PRK05476
      Location:82 → 502
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
      pfam05221
      Location:82 → 507
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    4. XM_005205708.5 → XP_005205765.1  adenosylhomocysteinase 3 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LYW5, A0AAF6YIY7
      Conserved Domains (2) summary
      PRK05476
      Location:83 → 503
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
      pfam05221
      Location:83 → 508
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    5. XM_005205711.5 → XP_005205768.1  adenosylhomocysteinase 3 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1LYW5
      Conserved Domains (2) summary
      PRK05476
      Location:82 → 502
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
      pfam05221
      Location:82 → 507
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    6. XM_005205709.4 → XP_005205766.1  adenosylhomocysteinase 3 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LYW5
      Related
      ENSBTAP00070033235.1, ENSBTAT00070055322.1
      Conserved Domains (2) summary
      PRK05476
      Location:83 → 503
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
      pfam05221
      Location:83 → 508
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6QLP2.1 GenPept UniProtKB/Swiss-Prot:A6QLP2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials