TFPI2 tissue factor pathway inhibitor 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: TFPI2provided by VGNC
Official Full Name: tissue factor pathway inhibitor 2provided by VGNC
Primary source: VGNC:VGNC:35794
See related: BGD:BT23660; Ensembl:ENSBTAG00000015844
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	4	NC_037331.1 (11204080..11208388, complement)

Chromosome 4 - NC_037331.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bovine TFPI2 was cloned and its expression and characterization determined.
Title: Molecular cloning, expression, and characterization of bovine tissue factor pathway inhibitor-2.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tissue factor pathway inhibitor 2

Names: TFPI-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_182788.1 → NP_877589.1 tissue factor pathway inhibitor 2 precursor

See identical proteins and their annotated locations for NP_877589.1

Status: PROVISIONAL

Source sequence(s)

AY234861

UniProtKB/Swiss-Prot

Q7YRQ8

UniProtKB/TrEMBL

A0AAF6Z1X8

Related

ENSBTAP00000021062.4, ENSBTAT00000021062.5

Conserved Domains (2) summary

cd00109
Location:34 → 86

KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

pfam00014
Location:154 → 206

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain