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    POLA1 DNA polymerase alpha 1, catalytic subunit [ Bos taurus (domestic cattle) ]

    Gene ID: 534848, updated on 29-Jan-2025

    Summary

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    Official Symbol
    POLA1provided by VGNC
    Official Full Name
    DNA polymerase alpha 1, catalytic subunitprovided by VGNC
    Primary source
    VGNC:VGNC:33110
    See related
    BGD:BT11013; Ensembl:ENSBTAG00000008170
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See POLA1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (118341561..118636687, complement)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A Neighboring gene aristaless related homeobox Neighboring gene large ribosomal subunit protein uL13-like Neighboring gene small Cajal body-specific RNA 24 Neighboring gene small nucleolar RNA SNORA12 Neighboring gene phosphate cytidylyltransferase 1B, choline Neighboring gene microRNA mir-2285bf-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The base substitution fidelity of eucaryotic DNA polymerases. Mispairing frequencies, site preferences, insertion preferences, and base substitution by dislocation. Kunkel TA, et al. J Biol Chem, 1986 Jan 5. PMID 3941068
    2. The mutational specificity of DNA polymerases-alpha and -gamma during in vitro DNA synthesis. Kunkel TA. J Biol Chem, 1985 Oct 15. PMID 3930505
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mismatch repair rates and error analysis for calf DNA pol alpha & gamma
      Title: The base substitution fidelity of eucaryotic DNA polymerases. Mispairing frequencies, site preferences, insertion preferences, and base substitution by dislocation.
    2. DNA pol error rates & error types for calf DNA pol alpha & gamma
      Title: The mutational specificity of DNA polymerases-alpha and -gamma during in vitro DNA synthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC157406

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA replication origin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lagging strand elongation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in leading strand elongation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of alpha DNA polymerase:primase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA polymerase alpha catalytic subunit
    Names
    polymerase (DNA directed), alpha 1, catalytic subunit
    NP_001192994.1
    XP_005228413.1
    XP_005228416.1
    XP_005228417.1
    XP_024843893.1
    XP_059739465.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206065.1 → NP_001192994.1  DNA polymerase alpha catalytic subunit

      See identical proteins and their annotated locations for NP_001192994.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000030
      UniProtKB/TrEMBL
      A0AAA9THK8
      Conserved Domains (5) summary
      cd05776
      Location:535 → 767
      DNA_polB_alpha_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase
      cd05532
      Location:832 → 1242
      POLBc_alpha; DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively ...
      TIGR00592
      Location:50 → 1225
      pol2; DNA polymerase (pol2)
      pfam08996
      Location:1265 → 1455
      zf-DNA_Pol; DNA Polymerase alpha zinc finger
      pfam12254
      Location:35 → 95
      DNA_pol_alpha_N; DNA polymerase alpha subunit p180 N terminal

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      118341561..118636687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059883482.1 → XP_059739465.1  DNA polymerase alpha catalytic subunit isoform X2

      UniProtKB/TrEMBL
      A0AAA9THK8

    2. XM_005228356.5 → XP_005228413.1  DNA polymerase alpha catalytic subunit isoform X1

      UniProtKB/TrEMBL
      A0AAA9THK8
      Related
      ENSBTAP00070044534.1, ENSBTAT00070073120.1
      Conserved Domains (5) summary
      cd05776
      Location:541 → 773
      DNA_polB_alpha_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase
      cd05532
      Location:838 → 1248
      POLBc_alpha; DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively ...
      TIGR00592
      Location:56 → 1231
      pol2; DNA polymerase (pol2)
      pfam08996
      Location:1271 → 1461
      zf-DNA_Pol; DNA Polymerase alpha zinc finger
      pfam12254
      Location:41 → 101
      DNA_pol_alpha_N; DNA polymerase alpha subunit p180 N terminal

    3. XM_024988125.2 → XP_024843893.1  DNA polymerase alpha catalytic subunit isoform X5

      UniProtKB/TrEMBL
      A0AAA9SXC0
      Related
      ENSBTAP00070044450.1, ENSBTAT00070072987.1
      Conserved Domains (2) summary
      TIGR00592
      Location:56 → 1231
      pol2; DNA polymerase (pol2)
      pfam08996
      Location:1271 → 1388
      zf-DNA_Pol; DNA Polymerase alpha zinc finger

    4. XM_005228360.5 → XP_005228417.1  DNA polymerase alpha catalytic subunit isoform X4

      UniProtKB/TrEMBL
      A0AAA9SXC0, A0AAA9TCI6
      Related
      ENSBTAP00070044370.1, ENSBTAT00070072858.1
      Conserved Domains (5) summary
      cd05776
      Location:541 → 773
      DNA_polB_alpha_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase
      cd05532
      Location:838 → 1248
      POLBc_alpha; DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively ...
      TIGR00592
      Location:56 → 1231
      pol2; DNA polymerase (pol2)
      pfam08996
      Location:1271 → 1392
      zf-DNA_Pol; DNA Polymerase alpha zinc finger
      pfam12254
      Location:41 → 101
      DNA_pol_alpha_N; DNA polymerase alpha subunit p180 N terminal

    5. XM_005228359.5 → XP_005228416.1  DNA polymerase alpha catalytic subunit isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LMS8, A0AAA9SXC0
      Related
      ENSBTAP00070044335.1, ENSBTAT00070072805.1
      Conserved Domains (5) summary
      cd05776
      Location:541 → 773
      DNA_polB_alpha_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase
      cd05532
      Location:838 → 1248
      POLBc_alpha; DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively ...
      TIGR00592
      Location:56 → 1231
      pol2; DNA polymerase (pol2)
      pfam08996
      Location:1271 → 1388
      zf-DNA_Pol; DNA Polymerase alpha zinc finger
      pfam12254
      Location:41 → 101
      DNA_pol_alpha_N; DNA polymerase alpha subunit p180 N terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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