TERF2IP TERF2 interacting protein [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: TERF2IPprovided by VGNC
Official Full Name: TERF2 interacting proteinprovided by VGNC
Primary source: VGNC:VGNC:50057
See related: BGD:BT13401; EnsemblRapid:ENSBTAG00070018687
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	18	NC_037345.1 (2937400..2943919)

Chromosome 18 - NC_037345.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rap1 activation was dependent on PKA and required Src family kinases and the Rap1 exchanger C3G.
Title: Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables telomeric DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed
involved_in telomere maintenance via telomere lengthening	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of shelterin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: telomeric repeat-binding factor 2-interacting protein 1

Names: RAP1 homolog; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; repressor/activator protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001075412.2 → NP_001068880.1 telomeric repeat-binding factor 2-interacting protein 1

See identical proteins and their annotated locations for NP_001068880.1

Status: PROVISIONAL

Source sequence(s)

BC120017

UniProtKB/Swiss-Prot

Q0VCT3

Related

ENSBTAP00070025199.1, ENSBTAT00070042234.1

Conserved Domains (3) summary

pfam08914
Location:134 → 198

Myb_DNA-bind_2; Rap1 Myb domain

pfam16589
Location:17 → 100

BRCT_2; BRCT domain, a BRCA1 C-terminus domain

cl13131
Location:306 → 399

rap1_RCT; C-terminal domain of RAP1 recruits proteins to telomeres