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    PDGFRB platelet derived growth factor receptor beta [ Bos taurus (domestic cattle) ]

    Gene ID: 527165, updated on 1-Jan-2025

    Summary

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    Official Symbol
    PDGFRBprovided by VGNC
    Official Full Name
    platelet derived growth factor receptor betaprovided by VGNC
    Primary source
    VGNC:VGNC:32693
    See related
    BGD:BT20794; Ensembl:ENSBTAG00000002804
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
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    Genomic context

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    See PDGFRB in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (61473643..61511234, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene HMG-box containing 3 Neighboring gene colony stimulating factor 1 receptor Neighboring gene microRNA mir-1777b Neighboring gene caudal type homeobox 1 Neighboring gene U1 spliceosomal RNA Neighboring gene solute carrier family 6 member 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Bovine papillomavirus E5 oncoprotein binds to the activated form of the platelet-derived growth factor beta receptor in naturally occurring bovine urinary bladder tumours. Borzacchiello G, et al. Oncogene, 2006 Feb 23. PMID 16205631
    2. Identification of amino acids in the transmembrane and juxtamembrane domains of the platelet-derived growth factor receptor required for productive interaction with the bovine papillomavirus E5 protein. Petti LM, et al. J Virol, 1997 Oct. PMID 9311809, Free PMC Article
    3. Genetic effects of PDGFRB and MARCH1 identified in GWAS revealing strong associations with semen production traits in Chinese Holstein bulls. Liu S, et al. BMC Genet, 2017 Jul 3. PMID 28673243, Free PMC Article
    4. Hypoxia induces unique proliferative response in adventitial fibroblasts by activating PDGFβ receptor-JNK1 signalling. Panzhinskiy E, et al. Cardiovasc Res, 2012 Aug 1. PMID 22735370, Free PMC Article
    5. Synteny mapping in the bovine: genes from human chromosome 5. Zhang N, et al. Genomics, 1992 Sep. PMID 1385298

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study demonstrated the significant associations of genetic variants of the PDGFRB and MARCH1 genes with semen production traits.
      Title: Genetic effects of PDGFRB and MARCH1 identified in GWAS revealing strong associations with semen production traits in Chinese Holstein bulls.
    2. Suggest that hypoxia-induced modified cells engage the PDGFbeta-R-JNK1 axis to confer distinctively heightened proliferation and adventitial remodelling in pulmonary hypertension.
      Title: Hypoxia induces unique proliferative response in adventitial fibroblasts by activating PDGFβ receptor-JNK1 signalling.
    3. The data show for the first time an important interactive relationship between SERT and the PDGFRbeta in the production of pulmonary artery smooth muscle cell proliferation triggered by PDGF.
      Title: Serotonin transporter interacts with the PDGFβ receptor in PDGF-BB-induced signaling and mitogenesis in pulmonary artery smooth muscle cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables platelet-derived growth factor beta-receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables platelet-derived growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    platelet-derived growth factor receptor beta
    Names
    platelet-derived growth factor receptor, beta polypeptide
    NP_001069364.2
    XP_005209646.1
    XP_010805768.1
    XP_010805769.1
    XP_010805770.1
    XP_010805771.1
    XP_024850072.1
    XP_059744202.1
    XP_059744203.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075896.2 → NP_001069364.2  platelet-derived growth factor receptor beta precursor

      See identical proteins and their annotated locations for NP_001069364.2

      Status: VALIDATED

      Source sequence(s)
      AAFC03124370
      UniProtKB/TrEMBL
      A0AAA9SEB6
      Related
      ENSBTAP00000079213.1, ENSBTAT00000092229.1
      Conserved Domains (3) summary
      pfam00047
      Location:37 → 114
      ig; Immunoglobulin domain
      cl11960
      Location:313 → 414
      Ig; Immunoglobulin domain
      cl21453
      Location:561 → 952
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      61473643..61511234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059888220.1 → XP_059744203.1  platelet-derived growth factor receptor beta isoform X5

      UniProtKB/TrEMBL
      A0AAA9SEB6

    2. XM_010807467.4 → XP_010805769.1  platelet-derived growth factor receptor beta isoform X2

      See identical proteins and their annotated locations for XP_010805769.1

      UniProtKB/TrEMBL
      A0AAA9SEB6, F1N759
      Related
      ENSBTAP00000053664.3, ENSBTAT00000061140.4
      Conserved Domains (3) summary
      pfam00047
      Location:37 → 114
      ig; Immunoglobulin domain
      cl11960
      Location:313 → 414
      Ig; Immunoglobulin domain
      cl21453
      Location:575 → 966
      PKc_like; Protein Kinases, catalytic domain

    3. XM_010807469.4 → XP_010805771.1  platelet-derived growth factor receptor beta isoform X4

      UniProtKB/TrEMBL
      A0AAA9SEB6
      Conserved Domains (5) summary
      smart00410
      Location:206 → 293
      IG_like; Immunoglobulin like
      pfam00047
      Location:32 → 98
      ig; Immunoglobulin domain
      pfam07714
      Location:597 → 950
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:297 → 398
      Ig; Immunoglobulin domain
      cl21453
      Location:559 → 950
      PKc_like; Protein Kinases, catalytic domain

    4. XM_059888219.1 → XP_059744202.1  platelet-derived growth factor receptor beta isoform X5

      UniProtKB/TrEMBL
      A0AAA9SEB6

    5. XM_005209589.5 → XP_005209646.1  platelet-derived growth factor receptor beta isoform X3

      See identical proteins and their annotated locations for XP_005209646.1

      UniProtKB/TrEMBL
      A0A3Q1N3Z8, A0AAA9SEB6
      Related
      ENSBTAP00000064374.1, ENSBTAT00000086976.2
      Conserved Domains (3) summary
      pfam00047
      Location:41 → 118
      ig; Immunoglobulin domain
      cl11960
      Location:317 → 418
      Ig; Immunoglobulin domain
      cl21453
      Location:565 → 956
      PKc_like; Protein Kinases, catalytic domain

    6. XM_010807466.4 → XP_010805768.1  platelet-derived growth factor receptor beta isoform X1

      UniProtKB/TrEMBL
      A0AAA9SEB6
      Conserved Domains (3) summary
      pfam00047
      Location:41 → 118
      ig; Immunoglobulin domain
      cl11960
      Location:317 → 418
      Ig; Immunoglobulin domain
      cl21453
      Location:579 → 970
      PKc_like; Protein Kinases, catalytic domain

    7. XM_010807468.4 → XP_010805770.1  platelet-derived growth factor receptor beta isoform X2

      See identical proteins and their annotated locations for XP_010805770.1

      UniProtKB/TrEMBL
      A0AAA9SEB6, F1N759
      Conserved Domains (3) summary
      pfam00047
      Location:37 → 114
      ig; Immunoglobulin domain
      cl11960
      Location:313 → 414
      Ig; Immunoglobulin domain
      cl21453
      Location:575 → 966
      PKc_like; Protein Kinases, catalytic domain

    8. XM_024994304.2 → XP_024850072.1  platelet-derived growth factor receptor beta isoform X6

      UniProtKB/TrEMBL
      A0AAA9SEB6
      Conserved Domains (2) summary
      cl11960
      Location:152 → 253
      Ig; Immunoglobulin domain
      cl21453
      Location:400 → 791
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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