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    POT1 protection of telomeres 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 511292, updated on 30-Jan-2025

    Summary

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    Official Symbol
    POT1provided by VGNC
    Official Full Name
    protection of telomeres 1provided by VGNC
    Primary source
    VGNC:VGNC:33172
    See related
    BGD:BT29520; EnsemblRapid:ENSBTAG00070028746
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See POT1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (89092216..89190566, complement)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene G protein-coupled receptor 37 Neighboring gene developmentally-regulated GTP-binding protein 1-like Neighboring gene motile sperm domain-containing protein 1-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G-rich strand telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables telomerase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of telomere maintenance via telomerase IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in telomere capping IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of nuclear telomere cap complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protection of telomeres protein 1
    Names
    POT1 protection of telomeres 1 homolog
    protection of telomeres 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      89092216..89190566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005205670.5 → XP_005205727.2  protection of telomeres protein 1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9T0Y5, E1BGK3
      Conserved Domains (2) summary
      smart00976
      Location:158 → 288
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      pfam16686
      Location:300 → 445
      POT1PC; ssDNA-binding domain of telomere protection protein

    2. XM_015470412.3 → XP_015325898.2  protection of telomeres protein 1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9T0Y5, E1BGK3
      Conserved Domains (2) summary
      smart00976
      Location:158 → 288
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      pfam16686
      Location:300 → 445
      POT1PC; ssDNA-binding domain of telomere protection protein

    3. XM_024991139.2 → XP_024846907.1  protection of telomeres protein 1 isoform X3

      UniProtKB/TrEMBL
      A0AAA9S2Q7, E1BGK3
      Related
      ENSBTAP00070039521.1, ENSBTAT00070065435.1
      Conserved Domains (2) summary
      smart00976
      Location:103 → 233
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      pfam16686
      Location:245 → 390
      POT1PC; ssDNA-binding domain of telomere protection protein

    4. XM_024991138.2 → XP_024846906.1  protection of telomeres protein 1 isoform X2

      UniProtKB/TrEMBL
      A0AAA9TQZ6, E1BGK3
      Related
      ENSBTAP00070039496.1, ENSBTAT00070065410.1
      Conserved Domains (2) summary
      smart00976
      Location:142 → 272
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      pfam16686
      Location:284 → 429
      POT1PC; ssDNA-binding domain of telomere protection protein

    5. XM_005205667.5 → XP_005205724.2  protection of telomeres protein 1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9T0Y5, E1BGK3
      Related
      ENSBTAP00070039540.1, ENSBTAT00070065454.1
      Conserved Domains (2) summary
      smart00976
      Location:158 → 288
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      pfam16686
      Location:300 → 445
      POT1PC; ssDNA-binding domain of telomere protection protein

    6. XM_002686916.7 → XP_002686962.2  protection of telomeres protein 1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9T0Y5, E1BGK3
      Conserved Domains (2) summary
      smart00976
      Location:158 → 288
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      pfam16686
      Location:300 → 445
      POT1PC; ssDNA-binding domain of telomere protection protein

    7. XM_010804448.4 → XP_010802750.2  protection of telomeres protein 1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9T0Y5, E1BGK3
      Conserved Domains (2) summary
      smart00976
      Location:158 → 288
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      pfam16686
      Location:300 → 445
      POT1PC; ssDNA-binding domain of telomere protection protein

    8. XM_010804446.4 → XP_010802748.2  protection of telomeres protein 1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9T0Y5, E1BGK3
      Conserved Domains (2) summary
      smart00976
      Location:158 → 288
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      pfam16686
      Location:300 → 445
      POT1PC; ssDNA-binding domain of telomere protection protein

    9. XM_024991141.2 → XP_024846909.1  protection of telomeres protein 1 isoform X4

      UniProtKB/TrEMBL
      E1BGK3
      Conserved Domains (2) summary
      smart00976
      Location:11 → 141
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      pfam16686
      Location:153 → 298
      POT1PC; ssDNA-binding domain of telomere protection protein

    10. XM_059885930.1 → XP_059741913.1  protection of telomeres protein 1 isoform X4

      UniProtKB/TrEMBL
      E1BGK3
      Related
      ENSBTAP00070039484.1, ENSBTAT00070065394.1

    11. XM_024991142.2 → XP_024846910.1  protection of telomeres protein 1 isoform X4

      UniProtKB/TrEMBL
      E1BGK3
      Conserved Domains (2) summary
      smart00976
      Location:11 → 141
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      pfam16686
      Location:153 → 298
      POT1PC; ssDNA-binding domain of telomere protection protein
    Nucleotide Protein Strain
    Heading Accession and Version

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