GPAT4 glycerol-3-phosphate acyltransferase 4 [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: GPAT4
Gene description: glycerol-3-phosphate acyltransferase 4
See related: BGD:BT11355; Ensembl:ENSBTAG00000005730
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: AGPAT6
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 27

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	27	NC_037354.1 (36508852..36539760)

Chromosome 27 - NC_037354.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variants affecting the expression of AGPAT6 are causally involved in differential milk fat synthesis, with pleiotropic consequences for a diverse range of other milk components.
Title: Expression variants of the lipogenic AGPAT6 gene affect diverse milk composition phenotypes in Bos taurus.
The results of this study suggest that suggest that SLC27A6, ACSL1, FABP3, AGPAT6, and LPIN1 coordinately regulate the channeling of fatty acids toward copious milk fat synthesis in bovine mammary.
Title: ACSL1, AGPAT6, FABP3, LPIN1, and SLC27A6 are the most abundant isoforms in bovine mammary tissue and their expression is affected by stage of lactation.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables glycerol-3-phosphate O-acyltransferase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in triglyceride biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: glycerol-3-phosphate acyltransferase 4

Names: 1-AGP acyltransferase 6; 1-AGPAT 6; 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta); LPAAT-zeta; acyl-CoA:glycerol-3-phosphate acyltransferase 4; lysophosphatidic acid acyltransferase zeta

NP_001077138.1

EC 2.3.1.15

XP_059738179.1

EC 2.3.1.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083669.1 → NP_001077138.1 glycerol-3-phosphate acyltransferase 4 precursor

See identical proteins and their annotated locations for NP_001077138.1

Status: PROVISIONAL

Source sequence(s)

EF432784

UniProtKB/Swiss-Prot

A3FPG8

Related

ENSBTAP00000007532.4, ENSBTAT00000007532.6

Conserved Domains (1) summary

cd07991
Location:218 → 427

LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like