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    ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit [ Bos taurus (domestic cattle) ]

    Gene ID: 100125238, updated on 1-Jan-2025

    Summary

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    Official Symbol
    ERCC2provided by VGNC
    Official Full Name
    ERCC excision repair 2, TFIIH core complex helicase subunitprovided by VGNC
    Primary source
    VGNC:VGNC:28569
    See related
    Ensembl:ENSBTAG00000002072
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ERCC2 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (52982421..52998639, complement)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene microtubule affinity regulating kinase 4 Neighboring gene U6 spliceosomal RNA Neighboring gene creatine kinase, M-type Neighboring gene kinesin light chain 3 Neighboring gene protein phosphatase 1 regulatory subunit 13 like Neighboring gene RNA polymerase I subunit G Neighboring gene ERCC excision repair 1, endonuclease non-catalytic subunit Neighboring gene uncharacterized LOC112442336

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC166093

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of mitotic recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    general transcription and DNA repair factor IIH helicase subunit XPD
    Names
    CXPD
    DNA 5'-3' helicase XPD
    DNA excision repair protein ERCC-2
    DNA repair protein complementing XP-D cells
    TFIIH basal transcription factor complex helicase XPD subunit
    TFIIH basal transcription factor complex helicase subunit
    TFIIH subunit XPD
    excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)
    excision repair cross-complementing rodent repair deficiency, complementation group 6-like group 2
    xeroderma pigmentosum group D-complementing protein
    NP_001096787.1
    XP_015313622.1
    XP_024833672.1
    XP_059732467.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103317.1 → NP_001096787.1  general transcription and DNA repair factor IIH helicase subunit XPD

      See identical proteins and their annotated locations for NP_001096787.1

      Status: PROVISIONAL

      Source sequence(s)
      BC147982
      UniProtKB/Swiss-Prot
      A6QLJ0
      UniProtKB/TrEMBL
      A0AAF6YJ21
      Related
      ENSBTAP00000002680.7, ENSBTAT00000002680.7
      Conserved Domains (1) summary
      TIGR00604
      Location:7 → 708
      rad3; DNA repair helicase (rad3)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      52982421..52998639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059876484.1 → XP_059732467.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X2

      UniProtKB/TrEMBL
      A0AAA9TEU3, A0AAF6YJ21
      Related
      ENSBTAP00000095345.1, ENSBTAT00000093734.1

    2. XM_015458136.3 → XP_015313622.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LWZ9, A0AAF6YJ21
      Related
      ENSBTAP00000061990.1, ENSBTAT00000069093.2
      Conserved Domains (4) summary
      smart00488
      Location:48 → 320
      DEXDc2; DEAD-like helicases superfamily
      smart00491
      Location:582 → 726
      HELICc2; helicase superfamily c-terminal domain
      TIGR00604
      Location:47 → 748
      rad3; DNA repair helicase (rad3)
      pfam06777
      Location:312 → 453
      HBB; Helical and beta-bridge domain

    3. XM_024977904.2 → XP_024833672.1  general transcription and DNA repair factor IIH helicase subunit XPD isoform X3

      UniProtKB/TrEMBL
      A0A3Q1M3B7
      Conserved Domains (1) summary
      TIGR00604
      Location:47 → 709
      rad3; DNA repair helicase (rad3)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6QLJ0.1 GenPept UniProtKB/Swiss-Prot:A6QLJ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.