SLC4A1 solute carrier family 4 member 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: SLC4A1provided by VGNC
Official Full Name: solute carrier family 4 member 1provided by VGNC
Primary source: VGNC:VGNC:55870
See related: BGD:BT12701; Ensembl:ENSBTAG00000001610
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: BB3
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	19	NC_037346.1 (44066247..44082437, complement)

Chromosome 19 - NC_037346.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that a synthetic polypeptide containing the N terminus of bovine AE1 bound the Sec23A-Sec24C complex through a selective interaction with Sec24C.
Title: A new class of endoplasmic reticulum export signal PhiXPhiXPhi for transmembrane proteins and its selective interaction with Sec24C.
Single particle electron microscopy analysis of the bovine anion exchanger 1 reveals a flexible linker connecting the cytoplasmic and membrane domains.
Title: Single particle electron microscopy analysis of the bovine anion exchanger 1 reveals a flexible linker connecting the cytoplasmic and membrane domains.
These findings indicate that the conserved YXXPhi sequence or a noncanonical YXXXPhi sequence in the N-terminal region facilitates the endocytic recycling of erythroid AE1 through a clathrin-mediated pathway.
Title: Clathrin-mediated endocytosis of mammalian erythroid AE1 anion exchanger facilitated by a YXXΦ or a noncanonical YXXXΦ motif in the N-terminal stretch.
findings indicate that R664X AE1 nonsense mutant is forcibly extracted from the endoplasmic reticulum to reside in aggresomes through association with deltaF508-CFTR
Title: The forced aggresome formation of a bovine anion exchanger 1 (AE1) mutant through association with δF508-cystic fibrosis transmembrane conductance regulator upon proteasome inhibition in HEK293 cells.
These data demonstrate that the conserved amino acid residues Glu1, Leu2, Leu5, and Asp6 in the EL(K/Q)(L/C)LD(A/G)DD region have essential structural consequences in stable expression of AE1 at the plasma membrane.
Title: Structural implications of the EL(KIQ)(L/C)LD(A/G)DD sequence in the C-terminal cytoplasmic tail for proper targeting of anion exchanger 1 to the plasma membrane.
These findings indicate that AE1 R664X protein, which is associated with dominant hereditary spherocytosis, has a dominant-negative effect on the expression of wild-type AE1.
Title: Ubiquitylation-independent ER-associated degradation of an AE1 mutant associated with dominant hereditary spherocytosis in cattle.

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General gene information

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Markers

fb93h06.x1 (e-PCR)
- UniSTS:191806

GDB:178577 (e-PCR)
- UniSTS:155029

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables bicarbonate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info	PubMed
enables monoatomic anion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info	PubMed
enables solute:inorganic anion antiporter activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in bicarbonate transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in monoatomic anion transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of intracellular pH	IEA Inferred from Electronic Annotation more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: band 3 anion transport protein

Names: erythroid-specific band 3 protein; solute carrier family 4 member 1 (Diego blood group); solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181036.2 → NP_851379.1 band 3 anion transport protein

See identical proteins and their annotated locations for NP_851379.1

Status: PROVISIONAL

Source sequence(s)

AF163826

UniProtKB/TrEMBL

F6QNK2, Q9XSW5

Related

ENSBTAP00070035558.1, ENSBTAT00070059918.1

Conserved Domains (3) summary

TIGR00834
Location:69 → 929

ae; anion exchange protein

pfam00955
Location:390 → 856

HCO3_cotransp; HCO3- transporter family

pfam07565
Location:96 → 343

Band_3_cyto; Band 3 cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

Range

44066247..44082437 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005220818.5 → XP_005220875.1 band 3 anion transport protein isoform X1

See identical proteins and their annotated locations for XP_005220875.1

UniProtKB/TrEMBL

F6QNK2, Q9TUQ0

Conserved Domains (3) summary

TIGR00834
Location:1 → 854

ae; anion exchange protein

pfam00955
Location:315 → 781

HCO3_cotransp; HCO3- transporter family

pfam07565
Location:21 → 268

Band_3_cyto; Band 3 cytoplasmic domain