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    HDAC6 histone deacetylase 6 [ Bos taurus (domestic cattle) ]

    Gene ID: 513602, updated on 1-Jan-2025

    Summary

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    Official Symbol
    HDAC6provided by VGNC
    Official Full Name
    histone deacetylase 6provided by VGNC
    Primary source
    VGNC:VGNC:50613
    See related
    BGD:BT23879; Ensembl:ENSBTAG00000013244
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See HDAC6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (86915161..86934092)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene glyoxalase domain containing 5 Neighboring gene GATA binding protein 1 Neighboring gene ES cell expressed Ras Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Cigarette Smoke Disrupted Lung Endothelial Barrier Integrity and Increased Susceptibility to Acute Lung Injury via Histone Deacetylase 6. Borgas D, et al. Am J Respir Cell Mol Biol, 2016 May. PMID 26452072, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In coordination with increased HDAC6 phosphorylation, cigarette smoke extract inhibited Akt and activated glycogen synthase kinase (GSK)-3beta.
      Title: Cigarette Smoke Disrupted Lung Endothelial Barrier Integrity and Increased Susceptibility to Acute Lung Injury via Histone Deacetylase 6.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC157092

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables histone deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of histone deacetylase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone deacetylase 6
    NP_001092430.1
    XP_024843692.1
    XP_024843693.2
    XP_024843694.1
    XP_024843695.1
    XP_024843696.1
    XP_024843697.1
    XP_024843698.1
    XP_024843699.1
    XP_024843702.1
    XP_024843704.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098960.1 → NP_001092430.1  histone deacetylase 6

      See identical proteins and their annotated locations for NP_001092430.1

      Status: PROVISIONAL

      Source sequence(s)
      BC142298
      UniProtKB/TrEMBL
      A0A3Q1MEU9, A5PJZ7
      Related
      ENSBTAP00000072990.2, ENSBTAT00000078707.2
      Conserved Domains (4) summary
      cd10003
      Location:486 → 836
      HDAC6-dom2; Histone deacetylase 6, domain 2
      pfam02148
      Location:1047 → 1109
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl17011
      Location:99 → 435
      Arginase_HDAC; Arginase-like and histone-like hydrolases
      cl21453
      Location:865 → 989
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      86915161..86934092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024987934.2 → XP_024843702.1  histone deacetylase 6 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1M7Y1, A0AAA9RWE3
      Related
      ENSBTAP00000075399.1, ENSBTAT00000104426.1
      Conserved Domains (3) summary
      cd10003
      Location:486 → 836
      HDAC6-dom2; Histone deacetylase 6, domain 2
      cl17011
      Location:99 → 435
      Arginase_HDAC; Arginase-like and histone-like hydrolases
      cl21453
      Location:865 → 989
      PKc_like; Protein Kinases, catalytic domain

    2. XM_024987924.2 → XP_024843692.1  histone deacetylase 6 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MEU9, F1MQP3
      Related
      ENSBTAP00000017618.7, ENSBTAT00000017618.7
      Conserved Domains (4) summary
      cd10003
      Location:463 → 813
      HDAC6-dom2; Histone deacetylase 6, domain 2
      pfam02148
      Location:1024 → 1086
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl17011
      Location:99 → 412
      Arginase_HDAC; Arginase-like and histone-like hydrolases
      cl21453
      Location:842 → 966
      PKc_like; Protein Kinases, catalytic domain

    3. XM_024987925.2 → XP_024843693.2  histone deacetylase 6 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MEU9

    4. XM_024987936.2 → XP_024843704.2  histone deacetylase 6 isoform X4

    5. XM_024987927.2 → XP_024843695.1  histone deacetylase 6 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MEU9
      Related
      ENSBTAP00000069588.2, ENSBTAT00000069208.2
      Conserved Domains (4) summary
      cd10003
      Location:486 → 836
      HDAC6-dom2; Histone deacetylase 6, domain 2
      pfam02148
      Location:1047 → 1109
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl17011
      Location:99 → 435
      Arginase_HDAC; Arginase-like and histone-like hydrolases
      cl21453
      Location:865 → 989
      PKc_like; Protein Kinases, catalytic domain

    6. XM_024987931.2 → XP_024843699.1  histone deacetylase 6 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MEU9
      Conserved Domains (4) summary
      cd10003
      Location:486 → 836
      HDAC6-dom2; Histone deacetylase 6, domain 2
      pfam02148
      Location:1047 → 1109
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl17011
      Location:99 → 435
      Arginase_HDAC; Arginase-like and histone-like hydrolases
      cl21453
      Location:865 → 989
      PKc_like; Protein Kinases, catalytic domain

    7. XM_024987926.2 → XP_024843694.1  histone deacetylase 6 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MEU9
      Conserved Domains (4) summary
      cd10003
      Location:486 → 836
      HDAC6-dom2; Histone deacetylase 6, domain 2
      pfam02148
      Location:1047 → 1109
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl17011
      Location:99 → 435
      Arginase_HDAC; Arginase-like and histone-like hydrolases
      cl21453
      Location:865 → 989
      PKc_like; Protein Kinases, catalytic domain

    8. XM_024987929.2 → XP_024843697.1  histone deacetylase 6 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MEU9
      Conserved Domains (4) summary
      cd10003
      Location:486 → 836
      HDAC6-dom2; Histone deacetylase 6, domain 2
      pfam02148
      Location:1047 → 1109
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl17011
      Location:99 → 435
      Arginase_HDAC; Arginase-like and histone-like hydrolases
      cl21453
      Location:865 → 989
      PKc_like; Protein Kinases, catalytic domain

    9. XM_024987930.2 → XP_024843698.1  histone deacetylase 6 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MEU9
      Conserved Domains (4) summary
      cd10003
      Location:486 → 836
      HDAC6-dom2; Histone deacetylase 6, domain 2
      pfam02148
      Location:1047 → 1109
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl17011
      Location:99 → 435
      Arginase_HDAC; Arginase-like and histone-like hydrolases
      cl21453
      Location:865 → 989
      PKc_like; Protein Kinases, catalytic domain

    10. XM_024987928.2 → XP_024843696.1  histone deacetylase 6 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MEU9
      Conserved Domains (4) summary
      cd10003
      Location:486 → 836
      HDAC6-dom2; Histone deacetylase 6, domain 2
      pfam02148
      Location:1047 → 1109
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl17011
      Location:99 → 435
      Arginase_HDAC; Arginase-like and histone-like hydrolases
      cl21453
      Location:865 → 989
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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