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    BCKDHB branched chain keto acid dehydrogenase E1 subunit beta [ Bos taurus (domestic cattle) ]

    Gene ID: 282150, updated on 30-Jan-2025

    Summary

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    Official Symbol
    BCKDHBprovided by VGNC
    Official Full Name
    branched chain keto acid dehydrogenase E1 subunit betaprovided by VGNC
    Primary source
    VGNC:VGNC:97245
    See related
    BGD:BT23846; EnsemblRapid:ENSBTAG00070026248
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See BCKDHB in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (19804082..20074755)

    Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346203 Neighboring gene ELOVL fatty acid elongase 4 Neighboring gene TTK protein kinase Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene uncharacterized LOC132346204 Neighboring gene uncharacterized LOC104972971

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a complementary DNA clone coding for the E1 beta subunit of the bovine branched-chain alpha-ketoacid dehydrogenase complex: complete amino acid sequence of the precursor protein and its proteolytic processing. Nobukuni Y, et al. Biochemistry, 1990 Feb 6. PMID 2322554
    2. Cloning and expression in Escherichia coli of mature E1 beta subunit of bovine mitochondrial branched-chain alpha-keto acid dehydrogenase complex. Mapping of the E1 beta-binding region on E2. Wynn RM, et al. J Biol Chem, 1992 Jan 25. PMID 1730724
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC140675

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in branched-chain amino acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
    Names
    BCKDE1B
    BCKDH E1-beta
    branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease)
    branched-chain alpha-keto acid dehydrogenase E1 component beta chain
    NP_776932.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174507.2 → NP_776932.1  2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor

      See identical proteins and their annotated locations for NP_776932.1

      Status: PROVISIONAL

      Source sequence(s)
      M33323
      UniProtKB/TrEMBL
      A0AAA9T938
      Related
      ENSBTAP00070035217.1, ENSBTAT00070059401.1
      Conserved Domains (3) summary
      cd07036
      Location:75 → 241
      TPP_PYR_E1-PDHc-beta_like; Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins
      PTZ00182
      Location:66 → 390
      PTZ00182; 3-methyl-2-oxobutanate dehydrogenase; Provisional
      pfam02780
      Location:262 → 381
      Transketolase_C; Transketolase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      19804082..20074755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21839.2 GenPept UniProtKB/Swiss-Prot:P21839

    Gene LinkOut

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