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    DENND1A DENN domain containing 1A [ Bos taurus (domestic cattle) ]

    Gene ID: 514134, updated on 30-Jan-2025

    Summary

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    Official Symbol
    DENND1Aprovided by VGNC
    Official Full Name
    DENN domain containing 1Aprovided by VGNC
    Primary source
    VGNC:VGNC:27993
    See related
    BGD:BT16488; EnsemblRapid:ENSBTAG00070019449
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See DENND1A in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (94527719..95058757, complement)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene spermatid perinuclear RNA binding protein Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC132346632 Neighboring gene crumbs cell polarity complex component 2 Neighboring gene ribosomal protein S20 pseudogene Neighboring gene glycine cleavage system H protein, mitochondrial-like Neighboring gene uncharacterized LOC112448886 Neighboring gene uncharacterized LOC132346633 Neighboring gene LIM homeobox 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Genetic variations of bovine PCOS-related DENND1A gene identified in GWAS significantly affect female reproductive traits. Zheng J, et al. Gene, 2021 Nov 15. PMID 34352299
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic variations of bovine PCOS-related DENND1A gene identified in GWAS significantly affect female reproductive traits.
      Title: Genetic variations of bovine PCOS-related DENND1A gene identified in GWAS significantly affect female reproductive traits.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytic recycling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DENN domain-containing protein 1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193014.1 → NP_001179943.1  DENN domain-containing protein 1A

      See identical proteins and their annotated locations for NP_001179943.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000011
      UniProtKB/TrEMBL
      A0AAA9SES9
      Related
      ENSBTAP00070026486.1, ENSBTAT00070043997.1
      Conserved Domains (3) summary
      smart00801
      Location:305 → 371
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:95 → 273
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:9 → 91
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      94527719..95058757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059891201.1 → XP_059747184.1  DENN domain-containing protein 1A isoform X3

      UniProtKB/TrEMBL
      A0AAA9SES9

    2. XM_015473579.3 → XP_015329065.1  DENN domain-containing protein 1A isoform X2

      UniProtKB/TrEMBL
      A0AAA9SES9
      Conserved Domains (3) summary
      smart00801
      Location:305 → 371
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:95 → 273
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:9 → 91
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    3. XM_015473580.3 → XP_015329066.1  DENN domain-containing protein 1A isoform X4

      UniProtKB/TrEMBL
      A0AAA9SES9
      Related
      ENSBTAP00070026516.1, ENSBTAT00070044038.1
      Conserved Domains (3) summary
      smart00801
      Location:305 → 371
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:95 → 273
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:9 → 91
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    4. XM_005213126.5 → XP_005213183.1  DENN domain-containing protein 1A isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MGE0, A0AAA9SES9
      Related
      ENSBTAP00070026493.1, ENSBTAT00070044007.1
      Conserved Domains (3) summary
      smart00801
      Location:305 → 371
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:95 → 273
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:9 → 91
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    5. XM_024998568.2 → XP_024854336.1  DENN domain-containing protein 1A isoform X5

      UniProtKB/TrEMBL
      A0AAA9SZC8
      Conserved Domains (3) summary
      smart00801
      Location:305 → 371
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:95 → 273
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:9 → 91
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    6. XM_059891202.1 → XP_059747185.1  DENN domain-containing protein 1A isoform X6

      UniProtKB/TrEMBL
      A0AAA9SZC8
      Related
      ENSBTAP00070026468.1, ENSBTAT00070043971.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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