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    DGKA diacylglycerol kinase alpha [ Bos taurus (domestic cattle) ]

    Gene ID: 506348, updated on 27-Dec-2024

    Summary

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    Official Symbol
    DGKAprovided by VGNC
    Official Full Name
    diacylglycerol kinase alphaprovided by VGNC
    Primary source
    VGNC:VGNC:28024
    See related
    BGD:BT18017; Ensembl:ENSBTAG00000004018
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See DGKA in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (57353450..57375964, complement)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 2 Neighboring gene premelanosome protein Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene anaphase-promoting complex subunit 11-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC139979

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    diacylglycerol kinase alpha
    Names
    DAG kinase alpha
    DGK-alpha
    diacylglycerol kinase, alpha 80kDa
    diglyceride kinase alpha
    NP_001071328.1
    XP_005206587.3
    XP_024847251.1
    XP_024847252.1
    XP_059742182.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077860.1 → NP_001071328.1  diacylglycerol kinase alpha

      See identical proteins and their annotated locations for NP_001071328.1

      Status: PROVISIONAL

      Source sequence(s)
      BC126521
      UniProtKB/Swiss-Prot
      A0JN54
      UniProtKB/TrEMBL
      A0AAF7AII2
      Related
      ENSBTAP00000038002.3, ENSBTAT00000038186.4
      Conserved Domains (5) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:205 → 253
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      57353450..57375964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024991483.2 → XP_024847251.1  diacylglycerol kinase alpha isoform X2

      UniProtKB/Swiss-Prot
      A0JN54
      UniProtKB/TrEMBL
      A0AAF7AII2
      Conserved Domains (5) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:205 → 253
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    2. XM_024991484.2 → XP_024847252.1  diacylglycerol kinase alpha isoform X2

      UniProtKB/Swiss-Prot
      A0JN54
      UniProtKB/TrEMBL
      A0AAF7AII2
      Conserved Domains (5) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:205 → 253
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    3. XM_005206530.5 → XP_005206587.3  diacylglycerol kinase alpha isoform X1

      UniProtKB/TrEMBL
      A0AAF7A1N0, A0AAF7AII2
      Related
      ENSBTAP00000061573.2, ENSBTAT00000080837.2
      Conserved Domains (5) summary
      smart00045
      Location:559 → 740
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:417 → 538
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:245 → 293
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:46 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    4. XM_059886199.1 → XP_059742182.1  diacylglycerol kinase alpha isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0JN54.1 GenPept UniProtKB/Swiss-Prot:A0JN54

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