NFKB1 nuclear factor kappa B subunit 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: NFKB1provided by VGNC
Official Full Name: nuclear factor kappa B subunit 1provided by VGNC
Primary source: VGNC:VGNC:32043
See related: Ensembl:ENSBTAG00000020270
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	6	NC_037333.1 (22205849..22319260, complement)

Chromosome 6 - NC_037333.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Anti-mastitis SNV identification of NFkappaB1 in Chinese Holstein cows and the possible anti-inflammation role of NFkappaB1/p105 in bovine MECs.
Title: Anti-mastitis SNV identification of NFκB1 in Chinese Holstein cows and the possible anti-inflammation role of NFκB1/p105 in bovine MECs.
These results indicated that docosahexaenoic acid may attenuate lipopolysaccharide-stimulated inflammatory response in bovine mammary epithelial cells by suppressing NF-kappaB activation through a mechanism partly dependent on PPARgamma activation.
Title: Docosahexaenoic acid attenuates LPS-stimulated inflammatory response by regulating the PPARγ/NF-κB pathways in primary bovine mammary epithelial cells.
Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF expression through the activation of AP-1 and NF-kappaB in bovine mammary gland fibroblasts.
Title: Staphylococcus aureus induces TGF-β1 and bFGF expression through the activation of AP-1 and NF-κB transcription factors in bovine mammary gland fibroblasts.
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 expression by NF-kappaB-MT1-MMP-dependent and -independent pathway.
Title: Role of PKC-α in NF-κB-MT1-MMP-mediated activation of proMMP-2 by TNF-α in pulmonary artery smooth muscle cells.
MMP-1 promotes VEGFR2 expression and proliferation of endothelial cells through stimulation of PAR-1 and activation of NF-kappaB
Title: Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells.
dynamic compression stimulates cell proliferation and proteoglycan synthesis in the presence of IL-1beta and/or inhibitors of the MAPKs and NFkappaB and AP-1 signalling pathways
Title: Signal transduction pathways involving p38 MAPK, JNK, NFkappaB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1beta and dynamic compression.

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General gene information

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Markers

NFKB1 (e-PCR)
- UniSTS:278828

MARC_3148-3149:996679038:1 (e-PCR)
- UniSTS:269181

D11S3748 (e-PCR)
- UniSTS:152978

fb82h10.x1 (e-PCR)
- UniSTS:191701

MARC_33233-33234:1050348259:1 (e-PCR)
- UniSTS:466687

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: nuclear factor NF-kappa-B p105 subunit

Names: nuclear factor NF-kappa-B p105 subunit-like protein; nuclear factor of kappa light polypeptide enhancer in B-cells 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076409.1 → NP_001069877.1 nuclear factor NF-kappa-B p105 subunit

See identical proteins and their annotated locations for NP_001069877.1

Status: PROVISIONAL

Source sequence(s)

DQ464067

UniProtKB/TrEMBL

F1MKW9, Q1KNJ0

Related

ENSBTAP00000027016.5, ENSBTAT00000027016.6

Conserved Domains (8) summary

cd07935
Location:42 → 243

RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)

cd00204
Location:573 → 701

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01177
Location:250 → 351

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

cd08797
Location:813 → 887

Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105

pfam12796
Location:583 → 677

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:540 → 599

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:669 → 723

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:539 → 576

ANK; ANK repeat [structural motif]