ALAD aminolevulinate dehydratase [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: ALADprovided by VGNC
Official Full Name: aminolevulinate dehydrataseprovided by VGNC
Primary source: VGNC:VGNC:25802
See related: BGD:BT20594; Ensembl:ENSBTAG00000000251
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	8	NC_037335.1 (102642378..102652289, complement)

Chromosome 8 - NC_037335.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

MARC_5939-5940 (e-PCR)
- UniSTS:269615

MARC_5939-5940:997299455:1 (e-PCR)
- UniSTS:269615

MARC_17135-17136:1021046712:3 (e-PCR)
- UniSTS:268231

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables porphobilinogen synthase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in heme biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: delta-aminolevulinic acid dehydratase

Names: ALADH; aminolevulinate, delta-, dehydratase; porphobilinogen synthase

NP_001014895.1

EC 4.2.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014895.1 → NP_001014895.1 delta-aminolevulinic acid dehydratase

See identical proteins and their annotated locations for NP_001014895.1

Status: PROVISIONAL

Source sequence(s)

BT021592

UniProtKB/Swiss-Prot

Q58DK5

UniProtKB/TrEMBL

Q2KIL3

Related

ENSBTAP00000000315.4, ENSBTAT00000000315.5

Conserved Domains (1) summary

cd04824
Location:8 → 327

eu_ALAD_PBGS_cysteine_rich; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...