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    MRPL58 mitochondrial ribosomal protein L58 [ Homo sapiens (human) ]

    Gene ID: 3396, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MRPL58provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein L58provided by HGNC
    Primary source
    HGNC:HGNC:5359
    See related
    Ensembl:ENSG00000167862 MIM:603000; AllianceGenome:HGNC:5359
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DS1; DS-1; ICT1; mL62; MRP-L58
    Summary
    The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
    Expression
    Ubiquitous expression in heart (RPKM 10.6), kidney (RPKM 10.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MRPL58 in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (75012670..75021261)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75904464..75913007)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73008765..73017356)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72978097-72979046 Neighboring gene uncharacterized LOC124904058 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:72983565-72984066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72989567-72990068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72990069-72990568 Neighboring gene cerebellar degeneration related protein 2 like Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:73008409-73009092 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:73009093-73009775 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:73015923-73017122 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73021286-73021443 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73029803-73030784 Neighboring gene RNA, U6 small nuclear 362, pseudogene Neighboring gene tRNA-Arg (anticodon CCT) 1-1 Neighboring gene potassium channel tetramerization domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ICT1 knockdown inhibits breast cancer cell growth via induction of cell cycle arrest and apoptosis. Wang C, et al. Int J Mol Med, 2017 Apr. PMID 28290601
    2. A novel T-cell differentiation antigen expressed in immature human thymocytes and neuroglial cells. Bae YM, et al. Cell Immunol, 1995 Oct 1. PMID 7545548
    3. Identification of mRNAs that show modulated expression during colon carcinoma cell differentiation. van Belzen N, et al. Eur J Biochem, 1995 Dec 15. PMID 8575443
    4. Codon-reading specificities of mitochondrial release factors and translation termination at non-standard stop codons. Lind C, et al. Nat Commun, 2013. PMID 24352605
    5. Immature Colon Carcinoma Transcript-1 (ICT1) Expression Correlates with Unfavorable Prognosis and Survival in Patients with Colorectal Cancer. Lao X, et al. Ann Surg Oncol, 2016 Nov. PMID 27411551

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits Apoptosis via STAT3/BCL-2 Pathway.
      Title: ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits Apoptosis via STAT3/BCL-2 Pathway.
    2. miR-1301-3p inhibits cell proliferation via inducing cell cycle arrest and apoptosis through targeting ICT1, and might be a therapeutic target for BC.
      Title: MiR-1301-3p inhibits human breast cancer cell proliferation by regulating cell cycle progression and apoptosis through directly targeting ICT1.
    3. High ICT1 expression is associated with leukemia.
      Title: Knockdown of immature colon carcinoma transcript 1 induces suppression of proliferation, S-phase arrest and apoptosis in leukemia cells.
    4. ICT1 overexpression notably predicted poor prognosis of gastric cancer patients.
      Title: miR-205 regulation of ICT1 has an oncogenic potential via promoting the migration and invasion of gastric cancer cells.
    5. Study demonstrates that ICT1 overexpression correlates with malignant clinical features and poor prognosis of hepatocellular carcinoma (HCC) patients. Functionally, ICT1 promotes proliferation, cell cycle progression and inhibits apoptosis of HCC cells. ICT1 regulates the expressions of CDK1, cyclin B1, Bcl-2 and Bax, and is directly targeted by microRNA-134 (miR-134) in HCC cells.
      Title: Immature colon carcinoma transcript-1 promotes cell growth of hepatocellular carcinoma via facilitating cell cycle progression and apoptosis resistance.
    6. ICT1 may play a crucial role in promoting gastric cancer proliferation in vitro.
      Title: Immature colon carcinoma transcript-1 promotes proliferation of gastric cancer cells.
    7. The results provide direct evidence that localized feedbacks on Fat4-Ds1 complexes can give rise to planar cell polarity.
      Title: A synthetic planar cell polarity system reveals localized feedback on Fat4-Ds1 complexes.
    8. our preliminary study reveals the important role of ICT1 in NSCLC cells that knockdown of ICT1 significantly suppressed cell proliferation, arrested cell cycle though altering expression cell cycle regulators, and promoted cell apoptosis.
      Title: Knockdown of Immature Colon Carcinoma Transcript 1 Inhibits Proliferation and Promotes Apoptosis of Non-Small Cell Lung Cancer Cells.
    9. ICT1 knockdown significantly inhibited cell proliferation and migration, led to G2/M phase cell-cycle arrest, and triggered apoptosis via the intracellular AMPKa, SAPK/JNK, and PARP signaling pathways.
      Title: Immature Colon Carcinoma Transcript-1 (ICT1) Expression Correlates with Unfavorable Prognosis and Survival in Patients with Colorectal Cancer.
    10. ICT1 was significantly upregulated in diffuse large B-cell lymphoma tissues (DLBCL) and correlated with poor survival. Knockdown of ICT1 remarkably induced cell cycle G0/G phase arrest and apoptosis in DLBCL cells.
      Title: ICT1 predicts a poor survival and correlated with cell proliferation in diffuse large B-cell lymphoma.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aminoacyl-tRNA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminoacyl-tRNA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation release factor activity, codon nonspecific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation release factor activity, codon nonspecific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translational termination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rescue of stalled ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein mL62
    Names
    39S ribosomal protein L58, mitochondrial
    digestion substraction 1
    immature colon carcinoma transcript 1 protein
    mitochondrial large ribosomal subunit protein ICT1
    mitochondrial large ribosomal subunit protein mL62
    peptidyl-tRNA hydrolase ICT1, mitochondrial
    NP_001290194.1
    NP_001536.1
    XP_016880063.1
    XP_054171913.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303265.2 → NP_001290194.1  large ribosomal subunit protein mL62 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 3' coding region compared to variant 1, that causes a frameshift. The resulting isoform (2) has a longer and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC015335, BI870683, DB456649
      UniProtKB/Swiss-Prot
      Q14197
      Conserved Domains (1) summary
      cl23917
      Location:72 → 170
      RF-1; RF-1 domain

    2. NM_001545.3 → NP_001536.1  large ribosomal subunit protein mL62 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001536.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the predominant isoform (1).
      Source sequence(s)
      BC015335, DB456649
      Consensus CDS
      CCDS11711.1
      UniProtKB/Swiss-Prot
      B2RAD1, Q14197, Q53HM7, Q53Y11
      UniProtKB/TrEMBL
      J3KS15
      Related
      ENSP00000301585.5, ENST00000301585.10
      Conserved Domains (1) summary
      cl29584
      Location:72 → 202
      RF-1; RF-1 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      75012670..75021261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024574.2 → XP_016880063.1  large ribosomal subunit protein mL62 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      75904464..75913007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315938.1 → XP_054171913.1  large ribosomal subunit protein mL62 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14197.1 GenPept UniProtKB/Swiss-Prot:Q14197

    Gene LinkOut

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