U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    EFNA2 ephrin A2 [ Homo sapiens (human) ]

    Gene ID: 1943, updated on 10-Dec-2024

    Summary

    Official Symbol
    EFNA2provided by HGNC
    Official Full Name
    ephrin A2provided by HGNC
    Primary source
    HGNC:HGNC:3222
    See related
    Ensembl:ENSG00000099617 MIM:602756; AllianceGenome:HGNC:3222
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ELF-1; EPLG6; LERK6; HEK7-L; LERK-6
    Summary
    This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in small intestine (RPKM 3.0), colon (RPKM 2.7) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EFNA2 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1284227..1301431)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1253481..1270685)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1285872..1301430)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9695 Neighboring gene CIRBP antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1273486-1273669 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1275036-1275260 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9697 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13609 Neighboring gene cold inducible RNA binding protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1282586-1283432 Neighboring gene family with sequence similarity 174 member C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1284956-1285456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1285457-1285957 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1287962-1288548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1291327-1292207 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9699 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1293760-1294329 Neighboring gene ribosomal protein S15 pseudogene 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9700 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:1324501-1325014 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:1325015-1325526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9701 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1354759-1355644 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1361729-1362399 Neighboring gene PWWP domain containing 3A, DNA repair factor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1368468-1368968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1368969-1369469

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ephrin receptor binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance  
    involved_in bone remodeling  
    involved_in bone remodeling  
    involved_in cell-cell signaling PubMed 
    involved_in ephrin receptor signaling pathway  
    involved_in ephrin receptor signaling pathway  
    involved_in olfactory bulb development  
    involved_in osteoclast differentiation  
    involved_in osteoclast differentiation  
    Component Evidence Code Pubs
    located_in neuromuscular junction  
    located_in perikaryon  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in side of membrane  

    General protein information

    Preferred Names
    ephrin-A2
    Names
    HEK7 ligand
    eph-related receptor tyrosine kinase ligand 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405.4 → NP_001396.2  ephrin-A2 precursor

      See identical proteins and their annotated locations for NP_001396.2

      Status: REVIEWED

      Source sequence(s)
      AC004258
      Consensus CDS
      CCDS12061.1
      UniProtKB/Swiss-Prot
      O43921, O76020
      Related
      ENSP00000215368.1, ENST00000215368.4
      Conserved Domains (1) summary
      cd10425
      Location:35 → 171
      Ephrin-A_Ectodomain; Ectodomain of Ephrin A

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      1284227..1301431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026449.2 → XP_016881938.1  ephrin-A2 isoform X1

    2. XM_047438382.1 → XP_047294338.1  ephrin-A2 isoform X3

    3. XM_017026450.1 → XP_016881939.1  ephrin-A2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      1253481..1270685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320143.1 → XP_054176118.1  ephrin-A2 isoform X1

    2. XM_054320145.1 → XP_054176120.1  ephrin-A2 isoform X3

    3. XM_054320144.1 → XP_054176119.1  ephrin-A2 isoform X2

    Loading
    External link. Please review our privacy policy.