WWC3 WWC family member 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: WWC3provided by HGNC
Official Full Name: WWC family member 3provided by HGNC
Primary source: HGNC:HGNC:29237
See related: Ensembl:ENSG00000047644 MIM:301089; AllianceGenome:HGNC:29237
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BM042
Summary: This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. [provided by RefSeq, Sep 2011]
Annotation information: Annotation category: suggests misassembly
Expression: Ubiquitous expression in lung (RPKM 15.2), placenta (RPKM 10.3) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: Xp22.2

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (10015254..10144474)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (9597786..9727019)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (9983294..10112514)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WBP2 negatively regulates the Hippo pathway by competitively binding to WWC3 with LATS1 to promote non-small cell lung cancer progression.
Title: WBP2 negatively regulates the Hippo pathway by competitively binding to WWC3 with LATS1 to promote non-small cell lung cancer progression.
WWC3 interacted with T cell factor 4 (TCF4).
Title: WWC3 Inhibits Glioma Cell Proliferation Through Suppressing the Wnt/β-Catenin Signaling Pathway.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DXS410 (e-PCR)
- UniSTS:99608

WI-17390 (e-PCR)
- UniSTS:76834

DXS8188 (e-PCR)
- UniSTS:47928

AF003657 (e-PCR)
- UniSTS:94596

AF003659 (e-PCR)
- UniSTS:94598

AF003671 (e-PCR)
- UniSTS:94610

A004I46 (e-PCR)
- UniSTS:2222

G66296 (e-PCR)
- UniSTS:230137

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of organ growth	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of hippo signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein WWC3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_021467.2 RefSeqGene

Range

5001..133724

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_015691.5 → NP_056506.3 protein WWC3

Status: VALIDATED

Source sequence(s)

AC002365, AC121345, KC987947

Consensus CDS

CCDS14136.1

UniProtKB/Swiss-Prot

A8KA96, Q659C1, Q9BTQ1, Q9ULE0, T2C6S4

Related

ENSP00000370242.6, ENST00000380861.10

Conserved Domains (3) summary

cd08680
Location:727 → 850

C2_Kibra; C2 domain found in Human protein Kibra

pfam00397
Location:62 → 91

WW; WW domain

pfam05615
Location:127 → 244

THOC7; Tho complex subunit 7