BRAF B-Raf proto-oncogene, serine/threonine kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: BRAFprovided by HGNC
Official Full Name: B-Raf proto-oncogene, serine/threonine kinaseprovided by HGNC
Primary source: HGNC:HGNC:1097
See related: Ensembl:ENSG00000157764 MIM:164757; AllianceGenome:HGNC:1097
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NS7; B-raf; BRAF1; RAFB1; B-RAF1; BRAF-1
Summary: This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
Expression: Ubiquitous expression in testis (RPKM 6.6), brain (RPKM 5.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q34

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (140713328..140924929, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (142027505..142239131, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (140413128..140624729, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations.
Title: eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations.
Follicular cell-derived thyroid carcinomas harboring novel genetic BRAF[NON-V600E] mutations: real-world data obtained using a multigene panel.
Title: Follicular cell-derived thyroid carcinomas harboring novel genetic BRAF(NON-V600E) mutations: real-world data obtained using a multigene panel.
A real world analysis of secondary BRAF variations after targeted therapy resistance in driver gene positive NSCLC.
Title: A real world analysis of secondary BRAF variations after targeted therapy resistance in driver gene positive NSCLC.
BRAF mutation in myeloid neoplasm: incidences and clinical outcomes.
Title: BRAF mutation in myeloid neoplasm: incidences and clinical outcomes.
Decoding the Molecular Mechanisms of BRAF [V600E]-Induced Nevi Formation.
Title: Decoding the Molecular Mechanisms of BRAF (V600E)-Induced Nevi Formation.
Analysis of Immunohistochemical Expression of BRAF (V600E) Mutation in Serrated Colorectal Polyps: A Study from Tertiary Hospital in Oman.
Title: Analysis of Immunohistochemical Expression of BRAF (V600E) Mutation in Serrated Colorectal Polyps: A Study from Tertiary Hospital in Oman.
Non-canonical BRAF variants and rearrangements in hairy cell leukemia.
Title: Non-canonical BRAF variants and rearrangements in hairy cell leukemia.
Variation in KRAS/NRAS/BRAF-Mutation Status by Age, Sex, and Race/Ethnicity Among a Large Cohort of Patients with Metastatic Colorectal Cancer (mCRC).
Title: Variation in KRAS/NRAS/BRAF-Mutation Status by Age, Sex, and Race/Ethnicity Among a Large Cohort of Patients with Metastatic Colorectal Cancer (mCRC).
Heterogeneous pathogenesis of melanoma: BRAF mutations and beyond.
Title: Heterogeneous pathogenesis of melanoma: BRAF mutations and beyond.
RICTOR/mTORC2 downregulation in BRAF[V600E] melanoma cells promotes resistance to BRAF/MEK inhibition.
Title: RICTOR/mTORC2 downregulation in BRAF(V600E) melanoma cells promotes resistance to BRAF/MEK inhibition.

Submit: New GeneRIF Correction See all GeneRIFs (2522)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Cardiofaciocutaneous syndrome 1 MedGen: CN029449 OMIM: 115150 GeneReviews: Cardiofaciocutaneous Syndrome	Compare labs
Cetuximab response MedGen: CN077967 GeneReviews: Not available	Compare labs
Colorectal cancer MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome	Compare labs
Dabrafenib response MedGen: CN239586 GeneReviews: Not available	Compare labs
LEOPARD syndrome 3 MedGen: C3150971 OMIM: 613707 GeneReviews: Noonan Syndrome with Multiple Lentigines	Compare labs
Lung cancer MedGen: C0242379 OMIM: 211980 GeneReviews: Not available	Compare labs
Melanoma, cutaneous malignant, susceptibility to, 1 MedGen: C1835047 OMIM: 155600 GeneReviews: Not available	Compare labs
Noonan syndrome 1 MedGen: C4551602 OMIM: 163950 GeneReviews: Noonan Syndrome	Compare labs
Noonan syndrome 7 MedGen: C3150970 OMIM: 613706 GeneReviews: Noonan Syndrome	Compare labs
Panitumumab response MedGen: CN077999 GeneReviews: Not available	Compare labs
Vemurafenib response MedGen: CN239577 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2014-08-04) ClinGen Genome Curation Page Haploinsufficency Little evidence for dosage pathogenicity (Last evaluated 2014-08-04) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-35884 (e-PCR)
- UniSTS:18946

GDB:1317924 (e-PCR)
- UniSTS:24602

GDB:1318226 (e-PCR)
- UniSTS:20310

GDB:1318374 (e-PCR)
- UniSTS:27484

STS-T28237 (e-PCR)
- UniSTS:26491

D7S2227 (e-PCR)
- UniSTS:65428

D7S1672 (e-PCR)
- UniSTS:62114

RH122643 (e-PCR)
- UniSTS:135088

Braf (e-PCR), detects polymorphism
- UniSTS:259512

WI-17864 (e-PCR)
- UniSTS:55019

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables MAP kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables mitogen-activated protein kinase kinase binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	IEA Inferred from Electronic Annotation more info
involved_in CD4-positive, alpha-beta T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell differentiation in thymus	IEA Inferred from Electronic Annotation more info
involved_in T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nerve growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of protein localization to membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in face development	IEA Inferred from Electronic Annotation more info
involved_in head morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in myeloid progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fibroblast migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of D-glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of axon regeneration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in response to peptide hormone	IEA Inferred from Electronic Annotation more info
involved_in somatic stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in substrate adhesion-dependent cell spreading	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in thymus development	IEA Inferred from Electronic Annotation more info
involved_in thyroid gland development	IEA Inferred from Electronic Annotation more info
involved_in visual learning	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell body	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase B-raf

Names: 94 kDa B-raf protein; B-Raf proto-oncogene serine/threonine-protein kinase (p94); B-Raf serine/threonine-protein; murine sarcoma viral (v-raf) oncogene homolog B1; proto-oncogene B-Raf; v-raf murine sarcoma viral oncogene homolog B; v-raf murine sarcoma viral oncogene homolog B1

NP_001341538.1

EC 2.7.11.1

NP_001361173.1

EC 2.7.11.1

NP_001361187.1

EC 2.7.11.1

NP_001365396.1

EC 2.7.11.1

NP_001365397.1

EC 2.7.11.1

NP_001365398.1

EC 2.7.11.1

NP_001365399.1

EC 2.7.11.1

NP_001365400.1

EC 2.7.11.1

NP_001365401.1

EC 2.7.11.1

NP_001365402.1

EC 2.7.11.1

NP_001365403.1

EC 2.7.11.1

NP_001365404.1

EC 2.7.11.1

NP_004324.2

EC 2.7.11.1

XP_016868048.1

EC 2.7.11.1

XP_047276722.1

EC 2.7.11.1

XP_047276723.1

EC 2.7.11.1

XP_047276724.1

EC 2.7.11.1

XP_047276725.1

EC 2.7.11.1

XP_047276726.1

EC 2.7.11.1

XP_054214849.1

EC 2.7.11.1

XP_054214850.1

EC 2.7.11.1

XP_054214851.1

EC 2.7.11.1

XP_054214852.1

EC 2.7.11.1

XP_054214853.1

EC 2.7.11.1

XP_054214854.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007873.3 RefSeqGene

Range

5001..195753

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_299

mRNA and Protein(s)

NM_001354609.2 → NP_001341538.1 serine/threonine-protein kinase B-raf isoform 2

Status: REVIEWED

Source sequence(s)

AA975673, AC006006, AC006344, AC006347

Consensus CDS

CCDS87555.1

UniProtKB/TrEMBL

H7C560

Related

ENSP00000419060.2, ENST00000496384.7

Conserved Domains (3) summary

cd01816
Location:156 → 227

Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases

cd14062
Location:463 → 715

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

pfam00130
Location:235 → 280

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001374244.1 → NP_001361173.1 serine/threonine-protein kinase B-raf isoform 3

Status: REVIEWED

Source sequence(s)

AC006006, AC006344, AC006347

Consensus CDS

CCDS94218.1

UniProtKB/TrEMBL

A0A2U3TZI2

Related

ENSP00000288602.7, ENST00000288602.11

Conserved Domains (3) summary

cd14062
Location:503 → 755

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:154 → 232

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

pfam00130
Location:235 → 280

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001374258.1 → NP_001361187.1 serine/threonine-protein kinase B-raf isoform 4

Status: REVIEWED

Source sequence(s)

AC006006, AC006344, AC006347

Consensus CDS

CCDS94219.1

UniProtKB/TrEMBL

A0A2R8Y8E0

Related

ENSP00000496776.1, ENST00000644969.2

Conserved Domains (3) summary

cd14062
Location:503 → 755

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:154 → 232

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

cd20871
Location:230 → 289

C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
NM_001378467.1 → NP_001365396.1 serine/threonine-protein kinase B-raf isoform 5

Status: REVIEWED

Source sequence(s)

AC006006, AC006344, AC006347

Conserved Domains (3) summary

cd14062
Location:466 → 718

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:154 → 235

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

cd20871
Location:233 → 292

C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
NM_001378468.1 → NP_001365397.1 serine/threonine-protein kinase B-raf isoform 6

Status: REVIEWED

Source sequence(s)

AC006006, AC006344, AC006347

Conserved Domains (3) summary

cd14062
Location:463 → 709

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:154 → 232

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

cd20871
Location:230 → 289

C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
NM_001378469.1 → NP_001365398.1 serine/threonine-protein kinase B-raf isoform 7

Status: REVIEWED

Source sequence(s)

AC006006, AC006344, AC006347

Conserved Domains (3) summary

cd14062
Location:441 → 693

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:154 → 232

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

cd20871
Location:230 → 289

C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
NM_001378470.1 → NP_001365399.1 serine/threonine-protein kinase B-raf isoform 8

Status: REVIEWED

Source sequence(s)

AC006006, AC006344, AC006347

Conserved Domains (3) summary

cd14062
Location:429 → 681

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:120 → 198

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

cd20871
Location:196 → 255

C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
NM_001378471.1 → NP_001365400.1 serine/threonine-protein kinase B-raf isoform 9

Status: REVIEWED

Source sequence(s)

AC006006, AC006344, AC006347

Conserved Domains (3) summary

cd14062
Location:426 → 678

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:154 → 232

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

cd20871
Location:230 → 289

C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
NM_001378472.1 → NP_001365401.1 serine/threonine-protein kinase B-raf isoform 10

Status: REVIEWED

Source sequence(s)

AC006006, AC006344, AC006347

Conserved Domains (3) summary

cd14062
Location:411 → 663

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:102 → 180

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

cd20871
Location:178 → 237

C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
NM_001378473.1 → NP_001365402.1 serine/threonine-protein kinase B-raf isoform 11

Status: REVIEWED

Source sequence(s)

AC006006, AC006344, AC006347

Conserved Domains (3) summary

cd14062
Location:411 → 663

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:102 → 180

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

cd20871
Location:178 → 237

C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
NM_001378474.1 → NP_001365403.1 serine/threonine-protein kinase B-raf isoform 12

Status: REVIEWED

Source sequence(s)

AC006006, AC006344, AC006347

Conserved Domains (3) summary

cd14062
Location:463 → 710

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:154 → 232

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

cd20871
Location:230 → 289

C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
NM_001378475.1 → NP_001365404.1 serine/threonine-protein kinase B-raf isoform 13

Status: REVIEWED

Source sequence(s)

AC006006, AC006344, AC006347

Conserved Domains (3) summary

cd14062
Location:375 → 627

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd20871
Location:142 → 201

C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

cl28922
Location:81 → 144

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
NM_004333.6 → NP_004324.2 serine/threonine-protein kinase B-raf isoform 1

See identical proteins and their annotated locations for NP_004324.2

Status: REVIEWED

Source sequence(s)

AC006006, AC006344, AW971583, BC101757, DB454480, M95712

Consensus CDS

CCDS5863.1

UniProtKB/Swiss-Prot

A4D1T4, B6HY61, B6HY62, B6HY63, B6HY64, B6HY65, B6HY66, P15056, Q13878, Q3MIN6, Q9UDP8, Q9Y6T3

Related

ENSP00000493543.1, ENST00000646891.2

Conserved Domains (3) summary

cd01816
Location:156 → 227

Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases

cd14062
Location:463 → 715

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

pfam00130
Location:235 → 280

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

140713328..140924929 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017012559.2 → XP_016868048.1 serine/threonine-protein kinase B-raf isoform X1
XM_047420766.1 → XP_047276722.1 serine/threonine-protein kinase B-raf isoform X2
XM_047420770.1 → XP_047276726.1 serine/threonine-protein kinase B-raf isoform X6
XM_047420767.1 → XP_047276723.1 serine/threonine-protein kinase B-raf isoform X3
XM_047420768.1 → XP_047276724.1 serine/threonine-protein kinase B-raf isoform X4

UniProtKB/TrEMBL

A0A2R8YDP5
XM_047420769.1 → XP_047276725.1 serine/threonine-protein kinase B-raf isoform X5

UniProtKB/TrEMBL

A0A2R8YDP5

Related

ENSP00000494784.1, ENST00000646730.1

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

142027505..142239131 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054358874.1 → XP_054214849.1 serine/threonine-protein kinase B-raf isoform X1
XM_054358875.1 → XP_054214850.1 serine/threonine-protein kinase B-raf isoform X2
XM_054358879.1 → XP_054214854.1 serine/threonine-protein kinase B-raf isoform X6
XM_054358876.1 → XP_054214851.1 serine/threonine-protein kinase B-raf isoform X3
XM_054358877.1 → XP_054214852.1 serine/threonine-protein kinase B-raf isoform X4

UniProtKB/TrEMBL

A0A2R8YDP5
XM_054358878.1 → XP_054214853.1 serine/threonine-protein kinase B-raf isoform X5

UniProtKB/TrEMBL

A0A2R8YDP5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NR_148928.2: Suppressed sequence

Description

NR_148928.2: This RefSeq was removed because currently there is insufficient support for the transcript.