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    EAF6 Eaf6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853544, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EAF6
    Official Full Name
    Eaf6p
    Primary source
    SGD:S000003842
    Locus tag
    YJR082C
    See related
    AllianceGenome:SGD:S000003842; FungiDB:YJR082C; VEuPathDB:YJR082C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to contribute to histone acetyltransferase activity. Involved in DNA repair. Located in nucleus. Part of NuA3a histone acetyltransferase complex; NuA3b histone acetyltransferase complex; and NuA4 histone acetyltransferase complex. Orthologous to human MEAF6 (MYST/Esa1 associated factor 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EAF6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (581914..582255, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene dioxygenase BNA2 Neighboring gene uncharacterized protein Neighboring gene Aim24p Neighboring gene Acf4p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism. Xu P, et al. Mol Cell, 2016 Sep 15. PMID 27594449
    2. Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Taverna SD, et al. Mol Cell, 2006 Dec 8. PMID 17157260, Free PMC Article
    3. Identification and characterization of the activation domain of Ifh1, an activator of model TATA-less genes. Zhong P, et al. Biochem Biophys Res Commun, 2010 Jan 29. PMID 20059977
    4. Mapping the local protein interactome of the NuA3 histone acetyltransferase. Smart SK, et al. Protein Sci, 2009 Sep. PMID 19621382, Free PMC Article
    5. Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex. Nourani A, et al. Mol Cell Biol, 2001 Nov. PMID 11604499, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Eaf5/7/3 form a functionally independent NuA4 submodule linked to RNA polymerase II-coupled nucleosome recycling.
      Title: Eaf5/7/3 form a functionally independent NuA4 submodule linked to RNA polymerase II-coupled nucleosome recycling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to histone acetyltransferase activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA3 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NuA3a histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NuA3b histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Eaf6p
    NP_012615.3
    • Subunit of the NuA4 acetyltransferase complex; this complex acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      581914..582255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181739.3 → NP_012615.3  TPA: Eaf6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012615.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWQ1, P47128
      UniProtKB/TrEMBL
      A6ZQ38, C7GMC4, C8ZBM8, G2WH85, N1P057
      Conserved Domains (1) summary
      pfam09340
      Location:14 → 103
      NuA4; Histone acetyltransferase subunit NuA4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47128.1

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