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    HBP1 HMG-box transcription factor 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 515320, updated on 29-Jan-2025

    Summary

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    Official Symbol
    HBP1provided by VGNC
    Official Full Name
    HMG-box transcription factor 1provided by VGNC
    Primary source
    VGNC:VGNC:29767
    See related
    BGD:BT26147; Ensembl:ENSBTAG00000005524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See HBP1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (48265379..48296504)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112446374 Neighboring gene uncharacterized LOC104972045 Neighboring gene uncharacterized LOC132345086 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta Neighboring gene component of oligomeric golgi complex 5 Neighboring gene G protein-coupled receptor 22 Neighboring gene dihydrouridine synthase 4 like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC128984

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    HMG box-containing protein 1
    Names
    high mobility group box transcription factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046196.2 → NP_001039661.2  HMG box-containing protein 1

      See identical proteins and their annotated locations for NP_001039661.2

      Status: VALIDATED

      Source sequence(s)
      DT860509, DV805391, DV934925, EH164246, EV679089
      UniProtKB/TrEMBL
      A0A3S5ZPL4
      Related
      ENSBTAP00070032278.1, ENSBTAT00070053787.1
      Conserved Domains (2) summary
      smart00536
      Location:222 → 348
      AXH; domain in Ataxins and HMG containing proteins
      cd01388
      Location:441 → 512
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      48265379..48296504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059885563.1 → XP_059741546.1  HMG box-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q2KJ34
      UniProtKB/TrEMBL
      A0A3S5ZPL4

    2. XM_024990663.2 → XP_024846431.1  HMG box-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A3S5ZPL4, A0AAA9TTW0
      Related
      ENSBTAP00070032268.1, ENSBTAT00070053757.1
      Conserved Domains (2) summary
      smart00536
      Location:249 → 375
      AXH; domain in Ataxins and HMG containing proteins
      cd01388
      Location:468 → 539
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2KJ34.1 GenPept UniProtKB/Swiss-Prot:Q2KJ34

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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