PTX3 pentraxin 3 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PTX3provided by VGNC
Official Full Name: pentraxin 3provided by VGNC
Primary source: VGNC:VGNC:33566
See related: BGD:BT10420; Ensembl:ENSBTAG00000009012
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	1	NC_037328.1 (110158197..110164262, complement)

Chromosome 1 - NC_037328.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pentraxin 3 expression in lungs and neutrophils of calves.
Title: Pentraxin 3 expression in lungs and neutrophils of calves.
Serum H-FABP in cattle with traumatic pericarditis (TP) was significantly higher than in the control group and positively correlated with PTX-3 and thrombomodulin (TM). The serum levels of PTX-3 and TM in cattle with TP were significantly higher than in the control group.
Title: Heart-type fatty acid-binding protein (H-FABP), pentraxin-3 (PTX-3) and thrombomodulin in bovine traumatic pericarditis.
there is an FGF2-binding domain in the N-terminal extension of PTX3 spanning the PTX3-(97-110) region
Title: Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

MARC_17511-17512:1016472928:1 (e-PCR)
- UniSTS:268327

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables complement component C1q complex binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation by host of viral process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: pentraxin-related protein PTX3

Names: pentaxin-related protein PTX3; pentraxin 3, long; pentraxin-related gene, rapidly induced by IL-1 beta

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076259.2 → NP_001069727.1 pentraxin-related protein PTX3 precursor

See identical proteins and their annotated locations for NP_001069727.1

Status: PROVISIONAL

Source sequence(s)

BC120175

UniProtKB/Swiss-Prot

Q0VCG9

UniProtKB/TrEMBL

A0AAA9SX10

Related

ENSBTAP00000011863.4, ENSBTAT00000011863.5

Conserved Domains (1) summary

cl22861
Location:176 → 381

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...