ALPI alkaline phosphatase, intestinal [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: ALPI
Gene description: alkaline phosphatase, intestinal
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: IAP
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Genomic context

Location:: chromosome: 2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	2	NC_037329.1 (120096973..120100228)

Chromosome 2 - NC_037329.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

activity of intestinal alkaline phosphatase on a panel of structurally defined LPS chemotypes isolated from Escherichia coli and demonstrate that calf intestinal AP (cIAP) has only minimal activity against unmodified enteric LPS chemotypes
Title: Substrate structure-activity relationship reveals a limited lipopolysaccharide chemotype range for intestinal alkaline phosphatase.
Intravenous bolus administration plus 8 hours continuous infusion of alkaline phosphatase in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass results in endogenous alkaline phosphatase release.
Title: Prophylactic treatment with alkaline phosphatase in cardiac surgery induces endogenous alkaline phosphatase release.
Mechanism of IAP action appears to be through dephosphorylation of specific bacterial components, including LPS, CpG DNA, and flagellin, and not on live bacteria. IAP likely targets these bacterially derived molecules as gut mucosal defense factor.
Title: Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase.
Secondary structure of CIP after reaction with Co2+ in different conditions.
Title: Effect of metal ions on the secondary structure and activity of calf intestine phosphatase.
differences in metal binding between bovine and Escherichia coli alkaline phosphatases
Title: Distinct structure and activity recoveries reveal differences in metal binding between mammalian and Escherichia coli alkaline phosphatases.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

IAP (e-PCR), detects polymorphism
- UniSTS:250844

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables alkaline phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: intestinal-type alkaline phosphatase

Names: intestinal alkaline phosphatase V

NP_776412.2

EC 3.1.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173987.2 → NP_776412.2 intestinal-type alkaline phosphatase precursor

Status: VALIDATED

Source sequence(s)

NKLS02000002

UniProtKB/TrEMBL

A0A3Q1LSG5, A0A3Q1MG33

Conserved Domains (1) summary

pfam00245
Location:52 → 486

Alk_phosphatase; Alkaline phosphatase