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    HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase [ Bos taurus (domestic cattle) ]

    Gene ID: 407159, updated on 30-Jan-2025

    Summary

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    Official Symbol
    HMGCRprovided by VGNC
    Official Full Name
    3-hydroxy-3-methylglutaryl-CoA reductaseprovided by VGNC
    Primary source
    VGNC:VGNC:29879
    See related
    BGD:BT28784; EnsemblRapid:ENSBTAG00070026460
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    hmg-coa-r
    Orthologs
    human mouse all
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    Genomic context

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    See HMGCR in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (6764011..6784641)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 31 Neighboring gene cytochrome c oxidase subunit 7C, mitochondrial-like Neighboring gene transfer RNA tyrosine (anticodon GUA) Neighboring gene ceramide transporter 1 Neighboring gene DNA polymerase kappa

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. HMGR overexpression and interference affect the expression of steroidogenic genes and cholesterol content in bovine intramuscular adipocytes. Lin H, et al. Sci Rep, 2020 Oct 6. PMID 33024216, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HMGR overexpression and interference affect the expression of steroidogenic genes and cholesterol content in bovine intramuscular adipocytes.
      Title: HMGR overexpression and interference affect the expression of steroidogenic genes and cholesterol content in bovine intramuscular adipocytes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC166255

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in coenzyme A metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-hydroxy-3-methylglutaryl-coenzyme A reductase
    Names
    HMG-CoA reductase
    NP_001099083.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105613.1 → NP_001099083.1  3-hydroxy-3-methylglutaryl-coenzyme A reductase

      See identical proteins and their annotated locations for NP_001099083.1

      Status: PROVISIONAL

      Source sequence(s)
      BC153262
      UniProtKB/Swiss-Prot
      A7Z064, F1MMP6
      Related
      ENSBTAP00070035554.1, ENSBTAT00070059911.1
      Conserved Domains (3) summary
      cd00643
      Location:465 → 871
      HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
      TIGR00920
      Location:1 → 888
      2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
      cl21543
      Location:88 → 218
      MMPL; MMPL family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      6764011..6784641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A7Z064.2 GenPept UniProtKB/Swiss-Prot:A7Z064

    Gene LinkOut

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