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    HTR1B 5-hydroxytryptamine receptor 1B [ Bos taurus (domestic cattle) ]

    Gene ID: 317707, updated on 1-Jan-2025

    Summary

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    Official Symbol
    HTR1Bprovided by VGNC
    Official Full Name
    5-hydroxytryptamine receptor 1Bprovided by VGNC
    Primary source
    VGNC:VGNC:29992
    See related
    BGD:BT10520; Ensembl:ENSBTAG00000037429
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See HTR1B in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (17087755..17091930, complement)

    Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene uncharacterized LOC132346167 Neighboring gene transfer RNA alanine (anticodon UGC) Neighboring gene meiotic double-stranded break formation protein 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Serotonin receptor 1B (HTR1B) genotype associated with milk production traits in cattle. Zhang CL, et al. Res Vet Sci, 2008 Oct. PMID 18076958
    2. Quantitative mRNA analysis of eight bovine 5-HT receptor subtypes in brain, abomasum, and intestine by real-time RT-PCR. Reist M, et al. J Recept Signal Transduct Res, 2003. PMID 14753293
    3. Serotonin transporter interacts with the PDGFβ receptor in PDGF-BB-induced signaling and mitogenesis in pulmonary artery smooth muscle cells. Ren W, et al. Am J Physiol Lung Cell Mol Physiol, 2011 Mar. PMID 21186266, Free PMC Article
    4. Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin. Liu Y, et al. Circ Res, 2004 Sep 17. PMID 15297378
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data show for the first time an important interactive relationship between SERT and the PDGFRbeta in the production of pulmonary artery smooth muscle cell proliferation triggered by PDGF.
      Title: Serotonin transporter interacts with the PDGFβ receptor in PDGF-BB-induced signaling and mitogenesis in pulmonary artery smooth muscle cells.
    2. The relationship between polymorphisms at the HTR1B site and milk yield in Holstein cattle is reported.
      Title: Serotonin receptor 1B (HTR1B) genotype associated with milk production traits in cattle.
    3. Combinational action of SERT and a 5-HT receptor in SMC growth and Rho A/ROCK participation in 5-HT receptor 1B/1D-mediated mitogenesis of vascular SMCs through an effect on cytoplasmic to nuclear translocation of ERK1/ERK2.
      Title: Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin.
    4. analysis of eight bovine 5-HT receptor subtypes in brain, abomasum, and intestine by real-time RT-PCR
      Title: Quantitative mRNA analysis of eight bovine 5-HT receptor subtypes in brain, abomasum, and intestine by real-time RT-PCR.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables dopamine neurotransmitter receptor activity, coupled via Gs IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in bone remodeling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of behavior IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5-hydroxytryptamine receptor 1B
    Names
    5-hydroxytryptamine serotonin receptor 1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      17087755..17091930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024996920.2 → XP_024852688.1  5-hydroxytryptamine receptor 1B

      UniProtKB/TrEMBL
      F1MGM3
      Related
      ENSBTAP00000053759.3, ENSBTAT00000061041.4
      Conserved Domains (1) summary
      cd15333
      Location:61 → 393
      7tmA_5-HT1B_1D; serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version

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