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    PROC protein C, inactivator of coagulation factors Va and VIIIa [ Bos taurus (domestic cattle) ]

    Gene ID: 281428, updated on 29-Jan-2025

    Summary

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    Official Symbol
    PROCprovided by VGNC
    Official Full Name
    protein C, inactivator of coagulation factors Va and VIIIaprovided by VGNC
    Primary source
    VGNC:VGNC:56139
    See related
    BGD:BT11161; Ensembl:ENSBTAG00000003950
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PROC in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (5102056..5112592, complement)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene interacts with SUPT6H, CTD assembly factor 1 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene ras-related GTP-binding protein C-like Neighboring gene mitogen-activated protein kinase kinase kinase 2 Neighboring gene ERCC excision repair 3, TFIIH core complex helicase subunit Neighboring gene microRNA mir-2285aa

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Identification of activated protein C as a ghrelin endopeptidase in bovine plasma. Satou M, et al. J Endocrinol, 2015 Jan. PMID 25349251
    2. Amino acid sequence of the heavy chain of bovine protein C. Stenflo J, et al. J Biol Chem, 1982 Oct 25. PMID 6896877
    3. Amino acid sequence of the light chain of bovine protein C. Fernlund P, et al. J Biol Chem, 1982 Oct 25. PMID 6896876
    4. Structural changes required for activation of protein C are induced by Ca2+ binding to a high affinity site that does not contain gamma-carboxyglutamic acid. Johnson AE, et al. J Biol Chem, 1983 May 10. PMID 6406503
    5. Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C. Esmon NL, et al. J Biol Chem, 1983 May 10. PMID 6304092

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activated protein c is a ghrelin endopeptidase.
      Title: Identification of activated protein C as a ghrelin endopeptidase in bovine plasma.
    2. Activated protein C(APC) combined with protein S(PS) had significant antithrombotic effect. APC combined with PS prolonged clotting time. Dependence on APC-cofactor activity of PS for expression of anticoagulant activity by APC.
      Title: Prevention of thrombosis following deep arterial injury in rats by bovine activated protein C requiring co-administration of bovine protein S.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vitamin K-dependent protein C
    Names
    anticoagulant protein C
    autoprothrombin IIA
    blood coagulation factor XIV
    NP_001159984.1
    XP_015329858.1
    XP_024854240.1
    XP_059747484.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166512.1 → NP_001159984.1  vitamin K-dependent protein C precursor

      See identical proteins and their annotated locations for NP_001159984.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000002
      UniProtKB/Swiss-Prot
      P00745
      UniProtKB/TrEMBL
      A0A3Q1M616
      Related
      ENSBTAP00070002289.1, ENSBTAT00070004099.1
      Conserved Domains (5) summary
      smart00020
      Location:234 → 464
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:45 → 107
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:109 → 152
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:235 → 464
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:161 → 196
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      5102056..5112592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015474372.3 → XP_015329858.1  vitamin K-dependent protein C isoform X2

      UniProtKB/Swiss-Prot
      P00745
      Conserved Domains (5) summary
      smart00020
      Location:213 → 443
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:24 → 86
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:88 → 131
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:214 → 443
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:140 → 175
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_024998472.2 → XP_024854240.1  vitamin K-dependent protein C isoform X1

      UniProtKB/Swiss-Prot
      P00745
      UniProtKB/TrEMBL
      A0A140T851
      Related
      ENSBTAP00070002297.1, ENSBTAT00070004111.1
      Conserved Domains (4) summary
      smart00069
      Location:92 → 154
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:156 → 199
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:282 → 511
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:208 → 243
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    3. XM_059891501.1 → XP_059747484.1  vitamin K-dependent protein C isoform X2

      UniProtKB/Swiss-Prot
      P00745
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00745.1 GenPept UniProtKB/Swiss-Prot:P00745

    Gene LinkOut

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