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    ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 615535, updated on 28-Dec-2024

    Summary

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    Official Symbol
    ENPP1provided by VGNC
    Official Full Name
    ectonucleotide pyrophosphatase/phosphodiesterase 1provided by VGNC
    Primary source
    VGNC:VGNC:28504
    See related
    BGD:BT29873; Ensembl:ENSBTAG00000021830
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ENPP1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (69748257..69821533)

    Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 23 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 3 Neighboring gene cellular communication network factor 2 Neighboring gene monooxygenase DBH like 1 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The major acidic fibroblast growth factor (aFGF)-stimulated phosphoprotein from bovine liver plasma membranes has aFGF-stimulated kinase, autoadenylylation, and alkaline nucleotide phosphodiesterase activities. Oda Y, et al. J Biol Chem, 1993 Dec 25. PMID 7505270
    2. The plasma cell membrane glycoprotein, PC-1, is a threonine-specific protein kinase stimulated by acidic fibroblast growth factor. Oda Y, et al. J Biol Chem, 1991 Sep 5. PMID 1715869
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables dinucleotide phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphodiesterase I activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables polysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inorganic diphosphate transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nucleoside triphosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of bone mineralization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ectonucleotide pyrophosphatase/phosphodiesterase family member 1
    NP_001193141.1
    XP_010806874.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206212.1 → NP_001193141.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 1

      See identical proteins and their annotated locations for NP_001193141.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000009
      UniProtKB/TrEMBL
      A0AAA9SCY1, F1MNS5
      Related
      ENSBTAP00000053402.2, ENSBTAT00000061365.3
      Conserved Domains (4) summary
      smart00201
      Location:104 → 144
      SO; Somatomedin B -like domains
      smart00477
      Location:675 → 906
      NUC; DNA/RNA non-specific endonuclease
      pfam01663
      Location:212 → 538
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:210 → 578
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      69748257..69821533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010808572.4 → XP_010806874.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SCY1
      Conserved Domains (4) summary
      smart00201
      Location:104 → 144
      SO; Somatomedin B -like domains
      smart00477
      Location:635 → 866
      NUC; DNA/RNA non-specific endonuclease
      pfam01663
      Location:212 → 498
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:210 → 538
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
    Nucleotide Protein Strain
    Heading Accession and Version

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