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    USP33 ubiquitin specific peptidase 33 [ Bos taurus (domestic cattle) ]

    Gene ID: 531706, updated on 1-Jan-2025

    Summary

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    Official Symbol
    USP33provided by VGNC
    Official Full Name
    ubiquitin specific peptidase 33provided by VGNC
    Primary source
    VGNC:VGNC:36723
    See related
    BGD:BT27621; Ensembl:ENSBTAG00000020761
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See USP33 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (66900585..66959858)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene mitoguardin 1 Neighboring gene U6 spliceosomal RNA Neighboring gene zinc finger ZZ-type containing 3 Neighboring gene adenylate kinase 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 33
    Names
    deubiquitinating enzyme 33
    ubiquitin specific protease 33
    ubiquitin thioesterase 33
    ubiquitin thiolesterase 33
    ubiquitin-specific-processing protease 33
    NP_001094609.1
    XP_005204451.1
    XP_005204452.1
    XP_005204453.1
    XP_059740636.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101139.2 → NP_001094609.1  ubiquitin carboxyl-terminal hydrolase 33

      See identical proteins and their annotated locations for NP_001094609.1

      Status: PROVISIONAL

      Source sequence(s)
      BC148905
      UniProtKB/Swiss-Prot
      A6QNM7
      UniProtKB/TrEMBL
      A0AAF6Z8G7
      Related
      ENSBTAP00000027667.6, ENSBTAT00000027667.7
      Conserved Domains (6) summary
      smart00695
      Location:810 → 894
      DUSP; Domain in ubiquitin-specific proteases
      cd02674
      Location:443 → 683
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:155 → 284
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:153 → 682
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:30 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl12116
      Location:704 → 773
      DUSP; DUSP domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      66900585..66959858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005204394.4 → XP_005204451.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X1

      UniProtKB/TrEMBL
      A0AAF6Z8G7
      Conserved Domains (6) summary
      smart00695
      Location:802 → 886
      DUSP; Domain in ubiquitin-specific proteases
      cd02674
      Location:443 → 675
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:155 → 284
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:153 → 674
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:30 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl12116
      Location:696 → 765
      DUSP; DUSP domain

    2. XM_005204395.4 → XP_005204452.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LWB0, A0AAF6Z8G7
      Related
      ENSBTAP00000061503.1, ENSBTAT00000068919.2
      Conserved Domains (6) summary
      smart00695
      Location:763 → 847
      DUSP; Domain in ubiquitin-specific proteases
      COG5207
      Location:6 → 354
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd02674
      Location:396 → 636
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:153 → 635
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:30 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl12116
      Location:657 → 726
      DUSP; DUSP domain

    3. XM_059884653.1 → XP_059740636.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X4

      UniProtKB/TrEMBL
      A0AAF6Z8G7

    4. XM_005204396.5 → XP_005204453.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X3

      UniProtKB/TrEMBL
      A0AAF6Z8G7
      Conserved Domains (6) summary
      smart00695
      Location:646 → 730
      DUSP; Domain in ubiquitin-specific proteases
      cd02674
      Location:279 → 519
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:1 → 120
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:1 → 518
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam14797
      Location:108 → 215
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
      cl12116
      Location:540 → 609
      DUSP; DUSP domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6QNM7.1 GenPept UniProtKB/Swiss-Prot:A6QNM7

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