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    ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 404163, updated on 1-Jan-2025

    Summary

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    Official Symbol
    ST3GAL4provided by VGNC
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 4provided by VGNC
    Primary source
    VGNC:VGNC:35333
    See related
    Ensembl:ENSBTAG00000016506
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    SIAT4C; ST3GAL-IV
    Orthologs
    human mouse all
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    Genomic context

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    See ST3GAL4 in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (29698993..29739108)

    Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene ferritin light chain-like Neighboring gene decapping enzyme, scavenger Neighboring gene kirre like nephrin family adhesion molecule 3 Neighboring gene uncharacterized LOC132344192 Neighboring gene uncharacterized LOC132344188

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycolipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
    Names
    alpha2,3-sialyltransferase
    beta-galactoside alpha-2,3-sialyltransferase 4
    NP_991375.1
    XP_005226874.1
    XP_024842763.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205806.1 → NP_991375.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 precursor

      Status: PROVISIONAL

      Source sequence(s)
      AJ584673
      UniProtKB/TrEMBL
      A0A3Q1MGH3, F1MIZ3, Q70E76
      Conserved Domains (1) summary
      pfam00777
      Location:87 → 331
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      29698993..29739108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005226817.3 → XP_005226874.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MGH3, F1MIZ3, Q70E76
      Related
      ENSBTAP00000073357.2, ENSBTAT00000075324.2
      Conserved Domains (1) summary
      pfam00777
      Location:87 → 331
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_024986995.2 → XP_024842763.2  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M6Q2, A0A3Q1MGH3
      Related
      ENSBTAP00000065690.2, ENSBTAT00000077201.2
    Nucleotide Protein Strain
    Heading Accession and Version

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