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    OPN1LW opsin 1, long wave sensitive [ Bos taurus (domestic cattle) ]

    Gene ID: 282293, updated on 30-Jan-2025

    Summary

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    Gene symbol
    OPN1LW
    Gene description
    opsin 1, long wave sensitive
    See related
    BGD:BT27788; EnsemblRapid:ENSBTAG00070034403
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    OPSN
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    Genomic context

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    See OPN1LW in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (37321404..37333672)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor associated kinase 1 Neighboring gene methyl-CpG binding protein 2 Neighboring gene elongation factor 2-like Neighboring gene small ribosomal subunit protein eS27-like Neighboring gene testis expressed 28 Neighboring gene transketolase like 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Dynamics of bovine opsin bound to G-protein fragments. Sugihara M, et al. J Struct Biol, 2014 Oct. PMID 25138898
    2. Inherent instability of the retinitis pigmentosa P23H mutant opsin. Chen Y, et al. J Biol Chem, 2014 Mar 28. PMID 24515108, Free PMC Article
    3. Endoplasmic reticulum-associated degradation of a degron-containing polytopic membrane protein. Ray-Sinha A, et al. Mol Membr Biol, 2009 Dec. PMID 19878048, Free PMC Article
    4. Crystal structure of opsin in its G-protein-interacting conformation. Scheerer P, et al. Nature, 2008 Sep 25. PMID 18818650
    5. Parallel regulation of fetal gene expression in different photoreceptor cell types. van Ginkel PR, et al. J Biol Chem, 1994 Feb 18. PMID 8106474

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. an extended network of hydrogen bonds connects the agonist retinal binding site to the G protein binding site via conserved amino acid residues. dynamics of the hydrogen-bonding network inside opsin couples to interactions at the G protein binding site
      Title: Dynamics of bovine opsin bound to G-protein fragments.
    2. instability of the retinitis pigmentosa P23H mutant opsin
      Title: Inherent instability of the retinitis pigmentosa P23H mutant opsin.
    3. a single dibasic degron motif is sufficient to initiate both the ER retention and subsequent degradation of ospin via an endoplasmic reticulum associated degradation pathway
      Title: Endoplasmic reticulum-associated degradation of a degron-containing polytopic membrane protein.
    4. the crystal structure of ligand-free native opsin from bovine retinal rod cells at 2.9 angstrom (A) resolution
      Title: Crystal structure of the ligand-free G-protein-coupled receptor opsin.
    5. Mammalian rod opsin biogenesis does not appear to have an absolute requirement for Cnx.
      Title: Calnexin is not essential for mammalian rod opsin biogenesis.
    6. 3.2 A crystal structure of the bovine Ops*-GalphaCT peptide complex
      Title: Crystal structure of opsin in its G-protein-interacting conformation.
    7. Ligand binding in opsin apparently follows an induced-fit three-point interaction model, with the ring, 9-methyl group, and aldehyde group as the determining selection elements.
      Title: Constraints of the 9-methyl group binding pocket of the rhodopsin chromophore probed by 9-halogeno substitution.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled photoreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to light stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phototransduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in photoreceptor outer segment IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    long-wave-sensitive opsin 1
    Names
    opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan)
    red cone photoreceptor pigment
    red-sensitive opsin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174566.1 → NP_776991.1  long-wave-sensitive opsin 1

      See identical proteins and their annotated locations for NP_776991.1

      Status: PROVISIONAL

      Source sequence(s)
      AF280398
      UniProtKB/Swiss-Prot
      Q9BGI7
      Related
      ENSBTAP00070047186.1, ENSBTAT00070077403.1
      Conserved Domains (2) summary
      cd14964
      Location:56 → 80
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:42 → 333
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      37321404..37333672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BGI7.1 GenPept UniProtKB/Swiss-Prot:Q9BGI7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.