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    EXOSC3 exosome component 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 533245, updated on 29-Jan-2025

    Summary

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    Official Symbol
    EXOSC3provided by VGNC
    Official Full Name
    exosome component 3provided by VGNC
    Primary source
    VGNC:VGNC:28658
    See related
    BGD:BT29239; Ensembl:ENSBTAG00000018925
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See EXOSC3 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (61883370..61888055, complement)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 1 Neighboring gene tRNA methyltransferase 10B Neighboring gene uncharacterized LOC514189 Neighboring gene uncharacterized LOC104969378 Neighboring gene DDB1 and CUL4 associated factor 10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC127537

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CUT catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in TRAMP-dependent tRNA surveillance pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in U4 snRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nuclear polyadenylation-dependent rRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in poly(A)-dependent snoRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cytoplasmic exosome (RNase complex) IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of nuclear exosome (RNase complex) IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    exosome complex component RRP40
    Names
    exosome complex exonuclease RRP40
    ribosomal RNA-processing protein 40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035397.2 → NP_001030474.1  exosome complex component RRP40

      See identical proteins and their annotated locations for NP_001030474.1

      Status: PROVISIONAL

      Source sequence(s)
      BC102436
      UniProtKB/Swiss-Prot
      Q3T0E1
      Related
      ENSBTAP00070038262.1, ENSBTAT00070063731.1
      Conserved Domains (3) summary
      COG1097
      Location:26 → 274
      Rrp4; Exosome complex RNA-binding protein Rrp4, contains S1 and KH domains [Translation, ribosomal structure and biogenesis]
      cd05790
      Location:108 → 193
      S1_Rrp40; S1_Rrp40: Rrp40 S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Rrp4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation ...
      pfam15985
      Location:197 → 243
      KH_6; KH domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      61883370..61888055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3T0E1.1 GenPept UniProtKB/Swiss-Prot:Q3T0E1

    Gene LinkOut

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