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    MGP matrix Gla protein [ Bos taurus (domestic cattle) ]

    Gene ID: 282660, updated on 27-Dec-2024

    Summary

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    Gene symbol
    MGP
    Gene description
    matrix Gla protein
    See related
    BGD:BT11758
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MGP in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (95025128..95028639)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene Rho GDP dissociation inhibitor beta Neighboring gene endoplasmic reticulum protein 27 Neighboring gene ADP-ribosyltransferase 4 Neighboring gene chromosome 5 C12orf60 homolog Neighboring gene single-pass membrane protein with coiled-coil domains 3 Neighboring gene WW domain binding protein 11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Primary structure of bovine matrix Gla protein, a new vitamin K-dependent bone protein. Price PA, et al. J Biol Chem, 1985 Dec 5. PMID 3877721
    2. Effect of calcium and the calcimimetic AMG 641 on matrix-Gla protein in vascular smooth muscle cells. Mendoza FJ, et al. Calcif Tissue Int, 2011 Mar. PMID 21161195
    3. The cDNA and derived amino acid sequences for human and bovine matrix Gla protein. Kiefer MC, et al. Nucleic Acids Res, 1988 Jun 10. PMID 3387234, Free PMC Article
    4. Carboxyl-terminal proteolytic processing of matrix Gla protein. Hale JE, et al. J Biol Chem, 1991 Nov 5. PMID 1939157
    5. Matrix GLA protein stimulates VEGF expression through increased transforming growth factor-beta1 activity in endothelial cells. Boström K, et al. J Biol Chem, 2004 Dec 17. PMID 15456771

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Selective CaSR activation, either by extracellular calcium or AMG 641, increased MGP expression in vivo in the arterial wall and in vitro in bovine vascular smooth muscle cells.
      Title: Effect of calcium and the calcimimetic AMG 641 on matrix-Gla protein in vascular smooth muscle cells.
    2. Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein.
      Title: Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein.
    3. MGP plays a role in endothelial cell function, by increasing transforming growth factor-beta1 activity and stimulating VEGF expression
      Title: Matrix GLA protein stimulates VEGF expression through increased transforming growth factor-beta1 activity in endothelial cells.
    4. the effect of MGP on calcification and osteogenic differentiation is determined by availability of BMP-2
      Title: Matrix GLA protein and BMP-2 regulate osteoinduction in calcifying vascular cells.
    5. MGP has a novel binding activity for vitronectin
      Title: Matrix Gla protein C-terminal region binds to vitronectin. Co-localization suggests binding occurs during tissue development.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of bone mineralization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    matrix Gla protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174707.3 → NP_777132.1  matrix Gla protein precursor

      See identical proteins and their annotated locations for NP_777132.1

      Status: PROVISIONAL

      Source sequence(s)
      AF210379
      UniProtKB/Swiss-Prot
      P07507, Q54A30
      Conserved Domains (1) summary
      cl02449
      Location:31 → 96
      Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      95025128..95028639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07507.1 GenPept UniProtKB/Swiss-Prot:P07507

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