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    EIF2AK1 eukaryotic translation initiation factor 2 alpha kinase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 507689, updated on 1-Jan-2025

    Summary

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    Official Symbol
    EIF2AK1provided by VGNC
    Official Full Name
    eukaryotic translation initiation factor 2 alpha kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:28380
    See related
    BGD:BT20792; Ensembl:ENSBTAG00000007370
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See EIF2AK1 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 25 NC_037352.1 (38038513..38065440, complement)

    Chromosome 25 - NC_037352.1Genomic Context describing neighboring genes Neighboring gene radial spoke head 10 homolog B (Chlamydomonas) Neighboring gene PMS1 homolog 2, mismatch repair system component Neighboring gene aminoacyl tRNA synthetase complex interacting multifunctional protein 2 Neighboring gene ankyrin repeat domain 61 Neighboring gene ubiquitin specific peptidase 42 Neighboring gene microRNA mir-12052 Neighboring gene cytohesin 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC134528

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2-alpha kinase 1
    NP_001033142.1
    XP_005225109.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038053.2 → NP_001033142.1  eukaryotic translation initiation factor 2-alpha kinase 1

      See identical proteins and their annotated locations for NP_001033142.1

      Status: PROVISIONAL

      Source sequence(s)
      BC111252
      UniProtKB/TrEMBL
      Q2T9V3
      Related
      ENSBTAP00000009691.3, ENSBTAT00000009691.4
      Conserved Domains (2) summary
      smart00220
      Location:167 → 584
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14049
      Location:160 → 582
      STKc_EIF2AK1_HRI; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      38038513..38065440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005225052.5 → XP_005225109.1  eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TJW2
      Related
      ENSBTAP00000097459.1, ENSBTAT00000112994.1
      Conserved Domains (2) summary
      smart00220
      Location:167 → 620
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14049
      Location:160 → 618
      STKc_EIF2AK1_HRI; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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