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    SUPT5H SPT5 homolog, DSIF elongation factor subunit [ Bos taurus (domestic cattle) ]

    Gene ID: 519808, updated on 27-Dec-2024

    Summary

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    Official Symbol
    SUPT5Hprovided by VGNC
    Official Full Name
    SPT5 homolog, DSIF elongation factor subunitprovided by VGNC
    Primary source
    VGNC:VGNC:35481
    See related
    Ensembl:ENSBTAG00000010467
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SUPT5H in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (49132480..49159093)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S16 Neighboring gene interleukin 15-like Neighboring gene translocase of inner mitochondrial membrane 50 Neighboring gene delta like canonical Notch ligand 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC142813

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription elongation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transcription elongation-coupled chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DSIF complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription elongation factor SPT5
    Names
    suppressor of Ty 5 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083439.2 → NP_001076908.2  transcription elongation factor SPT5

      Status: PROVISIONAL

      Source sequence(s)
      BC134446
      UniProtKB/TrEMBL
      A0A3Q1MQ76, A7YW40
      Related
      ENSBTAP00000041740.4, ENSBTAT00000044229.4
      Conserved Domains (12) summary
      PRK08559
      Location:171 → 312
      nusG; transcription antitermination protein NusG; Validated
      cd09888
      Location:174 → 261
      NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
      COG5164
      Location:330 → 961
      SPT5; Transcription elongation factor [Transcription]
      cd06081
      Location:272 → 309
      KOW_Spt5_1; KOW domain of Spt5, repeat 1
      cd06082
      Location:416 → 466
      KOW_Spt5_2; KOW domain of Spt5, repeat 2
      cd06083
      Location:467 → 517
      KOW_Spt5_3; KOW domain of Spt5, repeat 3
      cd06084
      Location:593 → 635
      KOW_Spt5_4; KOW domain of Spt5, repeat 4
      cd06085
      Location:698 → 747
      KOW_Spt5_5; KOW domain of Spt5, repeat 5
      cd06086
      Location:1024 → 1080
      KOW_Spt5_6; KOW domain of Spt5, repeat 6
      pfam04731
      Location:843 → 972
      Caudal_act; Caudal like protein activation region
      pfam11942
      Location:75 → 167
      Spt5_N; Spt5 transcription elongation factor, acidic N-terminal
      pfam12815
      Location:762 → 818
      CTD; Spt5 C-terminal nonapeptide repeat binding Spt4

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      49132480..49159093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059876733.1 → XP_059732716.1  transcription elongation factor SPT5 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MQ76

    2. XM_024978257.2 → XP_024834025.1  transcription elongation factor SPT5 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MQ76
      Conserved Domains (5) summary
      cd09888
      Location:178 → 265
      NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
      cd06081
      Location:276 → 313
      KOW_Spt5_1; KOW domain of Spt5, repeat 1
      cd06086
      Location:1028 → 1084
      KOW_Spt5_6; KOW domain of Spt5, repeat 6
      pfam11942
      Location:75 → 171
      Spt5_N; Spt5 transcription elongation factor, acidic N-terminal
      cl26303
      Location:334 → 965
      CTD; Spt5 C-terminal nonapeptide repeat binding Spt4

    3. XM_024978256.2 → XP_024834024.1  transcription elongation factor SPT5 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MQ76
      Related
      ENSBTAP00000071865.2, ENSBTAT00000070366.2
      Conserved Domains (5) summary
      cd09888
      Location:178 → 265
      NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
      cd06081
      Location:276 → 313
      KOW_Spt5_1; KOW domain of Spt5, repeat 1
      cd06086
      Location:1028 → 1084
      KOW_Spt5_6; KOW domain of Spt5, repeat 6
      pfam11942
      Location:75 → 171
      Spt5_N; Spt5 transcription elongation factor, acidic N-terminal
      cl26303
      Location:334 → 965
      CTD; Spt5 C-terminal nonapeptide repeat binding Spt4

    4. XM_059876734.1 → XP_059732717.1  transcription elongation factor SPT5 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MQ76
    Nucleotide Protein Strain
    Heading Accession and Version

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